PMID- 15542732
OWN - NLM
STAT- MEDLINE
DCOM- 20050218
LR  - 20220316
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 1025
DP  - 2004 Oct
TI  - Gene polymorphisms of the mu opioid receptor in methamphetamine abusers.
PG  - 316-24
AB  - In drug addiction, the opioid system is thought to mediate motivational effects 
      through dopamine-independent mechanisms. We have investigated associations of the 
      mu-opioid receptor gene (OPRM) variations with methamphetamine (MAP) 
      dependence/psychosis. The allelic frequency of A118G (Asn40Asp) in exon 1 of ORPM 
      was 45.3% in our control subjects, but only 7.5-25.8% in the Caucasian or 
      African-American population of previous studies. We have identified several novel 
      polymorphisms in intron 1 and the 5' untranslated region (5'UTR) of OPRM. 
      Polymorphisms in the functionally relevant 5' regulatory region of OPRM were 
      different in our Japanese population from Caucasian or African-American 
      populations. No significant differences between controls and MAP abusers were 
      found in either genotype or allele frequency at any single nucleotide 
      polymorphism (SNP) or (AC)n dinucleotide repeat in intron 1. A subdivision of our 
      MAP group revealed that A118G of OPRM shows a significant association with MAP 
      psychosis having latency less than three years. Further analysis should be 
      capable of identifying associations between the OPRM variations and MAP 
      dependence/psychosis.
FAU - Ide, Soichiro
AU  - Ide S
AD  - Department of Molecular Psychiatry, Tokyo Institute of Psychiatry, Japan.
FAU - Kobayashi, Hideaki
AU  - Kobayashi H
FAU - Tanaka, Keiko
AU  - Tanaka K
FAU - Ujike, Hiroshi
AU  - Ujike H
FAU - Sekine, Yoshimoto
AU  - Sekine Y
FAU - Ozaki, Norio
AU  - Ozaki N
FAU - Inada, Toshiya
AU  - Inada T
FAU - Harano, Mutsuo
AU  - Harano M
FAU - Komiyama, Tokutaro
AU  - Komiyama T
FAU - Yamada, Mitsuhiko
AU  - Yamada M
FAU - Iyo, Masaomi
AU  - Iyo M
FAU - Ikeda, Kazutaka
AU  - Ikeda K
FAU - Sora, Ichiro
AU  - Sora I
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Receptors, Opioid, mu)
RN  - 44RAL3456C (Methamphetamine)
SB  - IM
MH  - Adult
MH  - Amphetamine-Related Disorders/*genetics/*metabolism
MH  - Chi-Square Distribution
MH  - Female
MH  - Gene Frequency/genetics
MH  - Humans
MH  - Male
MH  - *Methamphetamine
MH  - Monte Carlo Method
MH  - Polymorphism, Genetic/*genetics
MH  - Receptors, Opioid, mu/*genetics
EDAT- 2004/11/16 09:00
MHDA- 2005/02/19 09:00
CRDT- 2004/11/16 09:00
PHST- 2004/11/16 09:00 [pubmed]
PHST- 2005/02/19 09:00 [medline]
PHST- 2004/11/16 09:00 [entrez]
AID - 1025/1/316 [pii]
AID - 10.1196/annals.1316.039 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2004 Oct;1025:316-24. doi: 10.1196/annals.1316.039.