PMID- 15543221
OWN - NLM
STAT- MEDLINE
DCOM- 20050323
LR  - 20151119
VI  - 28 Suppl 3
DP  - 2004 Nov
TI  - Inflammatory mediators in overweight and obese Spanish adolescents. The AVENA 
      Study.
PG  - S59-63
AB  - OBJECTIVE: The aim of this study was to clarify if there is an association 
      between overweight and a state of chronic, low-grade inflammation in adolescents. 
      DESIGN: The study is a part of the cross-sectional multicenter study AVENA, 
      designed to evaluate the nutritional status of a representative sample of Spanish 
      adolescents. The adolescents were divided into two groups: (1) nonoverweight and 
      (2) overweight/obesity using the International Obesity Task Force (IOTF) 
      standards. SUBJECTS: A geographically representative subsample of the AVENA study 
      including 493 Spanish adolescents, aged 13-18 y (236 females/257 males), 
      participated in this study. MEASUREMENTS: Serum C-reactive protein (CRP) and in 
      vitro production of interleukin 6 and tumor necrosis factor alpha were measured, 
      together with a detailed anthropometry. RESULTS: The inflammatory markers showed 
      generally higher values in subjects with overweight/obesity than in those with 
      nonoverweight, with only CRP showing significant differences (the means were 0.83 
      and 1.27 mg/l in the nonoverweight and overweight/obesity groups, respectively). 
      CONCLUSION: Although we have not studied if adolescent overweight and obesity 
      play an initiating role in the development of future diseases, we suggest it may 
      induce a chronic low-grade inflammatory state, which points out the importance of 
      maintaining an appropriate body weight, to avoid obesity-related diseases in 
      adulthood.
FAU - Warnberg, J
AU  - Warnberg J
AD  - Immunonutrition Research Group, Department of Metabolism and Nutrition, Consejo 
      Superior de Investigaciones Cientificas, Madrid, Spain.
FAU - Moreno, L A
AU  - Moreno LA
FAU - Mesana, M I
AU  - Mesana MI
FAU - Marcos, A
AU  - Marcos A
CN  - AVENA group
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Obes Relat Metab Disord
JT  - International journal of obesity and related metabolic disorders : journal of the 
      International Association for the Study of Obesity
JID - 9313169
RN  - 0 (Biomarkers)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adolescent
MH  - Biomarkers/analysis/blood
MH  - C-Reactive Protein/analysis
MH  - Cells, Cultured
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Inflammation Mediators/*blood
MH  - Interleukin-6/analysis
MH  - Leukocytes, Mononuclear/immunology
MH  - Male
MH  - Nutrition Surveys
MH  - Obesity/*blood/immunology
MH  - Spain
MH  - Tumor Necrosis Factor-alpha/analysis
EDAT- 2004/11/16 09:00
MHDA- 2005/03/24 09:00
CRDT- 2004/11/16 09:00
PHST- 2004/11/16 09:00 [pubmed]
PHST- 2005/03/24 09:00 [medline]
PHST- 2004/11/16 09:00 [entrez]
AID - 0802809 [pii]
AID - 10.1038/sj.ijo.0802809 [doi]
PST - ppublish
SO  - Int J Obes Relat Metab Disord. 2004 Nov;28 Suppl 3:S59-63. doi: 
      10.1038/sj.ijo.0802809.