PMID- 15543584
OWN - NLM
STAT- MEDLINE
DCOM- 20050303
LR  - 20061115
IS  - 0146-6615 (Print)
IS  - 0146-6615 (Linking)
VI  - 75
IP  - 1
DP  - 2005 Jan
TI  - HHV-6 and 7 DNA loads in lung tissues collected from patients with interstitial 
      pneumonia.
PG  - 70-5
AB  - The aim of this study is to determine whether human herpesvirus 6 (HHV-6) and 
      HHV-7 might play an important role in causing interstitial pneumonia in patients 
      who have not undergone transplantation. HHV-6 and HHV-7 DNAs were quantitated by 
      real-time polymerase chain reaction (PCR) in paraffin embedded lung tissues 
      collected from 24 patients having the disease. Control tissues (without fibrosis) 
      were also collected from 19 of the 24 patients. Statistical analysis was carried 
      out by the Wilcoxon signed rank test or the Mann-Whitney U-test. HHV-6 DNA was 
      detected in 3 (12.5%) of the 24 target tissues and 3 (15.8%) of the 19 control 
      tissues, respectively. In contrast, HHV-7 DNA was detected in 19 (79.2%) of the 
      24 target tissues and 11 (57.9%) of the 19 control tissues. Neither HHV-6 DNA 
      load (P = 0.6395) nor HHV-7 DNA load (P = 0.5966) in target tissues differed 
      between males and females. Neither HHV-6 DNA load (P = 0.9589) nor HHV-7 DNA load 
      (P = 0.7419) in target tissues differed between cases with and without underlying 
      collagen disease. While HHV-6 DNA load did not differ between the target and 
      control tissues (P > 0.9999), the HHV-7 DNA load was significantly higher in the 
      target tissue than in the control tissue (P = 0.0298). This study suggests that 
      HHV-7 may play an important role in causing interstitial pneumonia in patients 
      who are not transplant recipients.
CI  - Copyright 2005 Wiley-Liss, Inc.
FAU - Yamamoto, Keizo
AU  - Yamamoto K
AD  - Division of Respiratory Medicine, Department of Internal Medicine, Nagoya 
      University Graduate School of Medicine, Nagoya, Aichi, Japan.
FAU - Yoshikawa, Tetsushi
AU  - Yoshikawa T
FAU - Okamoto, Souki
AU  - Okamoto S
FAU - Yamaki, Kenichi
AU  - Yamaki K
FAU - Shimokata, Kaoru
AU  - Shimokata K
FAU - Nishiyama, Yukihiro
AU  - Nishiyama Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Collagen Diseases/virology
MH  - DNA, Viral/*analysis
MH  - Female
MH  - Herpesvirus 6, Human/*isolation & purification
MH  - Herpesvirus 7, Human/*isolation & purification
MH  - Humans
MH  - Lung/*virology
MH  - Lung Diseases, Interstitial/*virology
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Statistics, Nonparametric
MH  - Viral Load
EDAT- 2004/11/16 09:00
MHDA- 2005/03/04 09:00
CRDT- 2004/11/16 09:00
PHST- 2004/11/16 09:00 [pubmed]
PHST- 2005/03/04 09:00 [medline]
PHST- 2004/11/16 09:00 [entrez]
AID - 10.1002/jmv.20239 [doi]
PST - ppublish
SO  - J Med Virol. 2005 Jan;75(1):70-5. doi: 10.1002/jmv.20239.