PMID- 15544860
OWN - NLM
STAT- MEDLINE
DCOM- 20051006
LR  - 20231213
IS  - 0167-0115 (Print)
IS  - 0167-0115 (Linking)
VI  - 124
IP  - 1-3
DP  - 2005 Jan 15
TI  - Nociceptin/orphanin FQ prevents ethanol-induced gastric lesions in the rat.
PG  - 203-7
AB  - Nociceptin/orphanin FQ (N/OFQ), the endogenous ligand of the NOP receptor, exerts 
      a variety of effects on the gastrointestinal tract. The present study was aimed 
      at evaluating the possible implication of N/OFQ in the maintenance of gastric 
      mucosal integrity. N/OFQ was given either centrally or peripherally 30 min prior 
      to intragastric administration (i.g.) of 1 ml/rat of ethanol (either 25% or 50%, 
      v/v), which produces macroscopically visible gastric lesions. 
      Intracerebroventricular (i.c.v.) injection of 2 microg/rat of N/OFQ significantly 
      reduced lesions caused by 50% ethanol, while 1 microg/rat was enough to 
      significantly reduce lesions caused by 25% ethanol. Intracerebroventricular 
      injection of 5 microg/rat of the selective NOP receptor antagonist, UFP-101, 
      completely reversed the protective effect of N/OFQ, 1 or 4 microg/rat against 25% 
      or 50% ethanol, respectively. The intraperitoneal (i.p.) injection of N/OFQ 
      produced a significant reduction of lesions induced by 50% ethanol, the peak 
      effect being observed at 10 microg/kg. Intraperitoneal pretreatment with UFP-101, 
      120 microg/kg, completely abolished the protective effect of peripherally 
      injected N/OFQ. Therefore, N/OFQ acts both centrally and peripherally as a 
      protective agent against ethanol-induced gastric lesions, and its effect is 
      mediated by NOP receptors.
FAU - Morini, Giuseppina
AU  - Morini G
AD  - Department of Human Anatomy, Pharmacology and Forensic Medicine, University of 
      Parma, 43100 Parma, Italy.
FAU - De Caro, Giuseppe
AU  - De Caro G
FAU - Guerrini, Remo
AU  - Guerrini R
FAU - Massi, Maurizio
AU  - Massi M
FAU - Polidori, Carlo
AU  - Polidori C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Regul Pept
JT  - Regulatory peptides
JID - 8100479
RN  - 0 (Opioid Peptides)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Animals
MH  - Ethanol/administration & dosage/*antagonists & inhibitors/*pharmacology
MH  - Gastric Mucosa/drug effects/pathology
MH  - Male
MH  - Opioid Peptides/metabolism/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Stomach Diseases/chemically induced/*pathology/*prevention & control
MH  - Nociceptin
EDAT- 2004/11/17 09:00
MHDA- 2005/10/07 09:00
CRDT- 2004/11/17 09:00
PHST- 2004/03/15 00:00 [received]
PHST- 2004/07/14 00:00 [revised]
PHST- 2004/07/15 00:00 [accepted]
PHST- 2004/11/17 09:00 [pubmed]
PHST- 2005/10/07 09:00 [medline]
PHST- 2004/11/17 09:00 [entrez]
AID - S0167-0115(04)00251-4 [pii]
AID - 10.1016/j.regpep.2004.07.016 [doi]
PST - ppublish
SO  - Regul Pept. 2005 Jan 15;124(1-3):203-7. doi: 10.1016/j.regpep.2004.07.016.