PMID- 15545735
OWN - NLM
STAT- MEDLINE
DCOM- 20050608
LR  - 20121115
IS  - 1424-859X (Electronic)
IS  - 1424-8581 (Linking)
VI  - 108
IP  - 1-3
DP  - 2005
TI  - Comparative mapping of human claudin-1 (CLDN1) in great apes.
PG  - 229-33
AB  - The gene encoding claudin-1 (CLDN1) has been mapped to human chromosome 3 (HSA3; 
      3q28-->q29) using a radiation hybrid panel. Employing fluorescence in situ 
      hybridization (FISH) we here show that a human P1-derived artificial chromosome 
      (PAC) containing CLDN1 detects the orthologous sites in chromosomes of the great 
      apes, chimpanzee, gorilla, and orangutan. Furthermore, the chromosomal position 
      of CLDN1 was determined in mouse chromosomes by FISH. The position of fluorescent 
      signals is confined to a single chromosomal site in both great apes and mouse and 
      in each case maps to the chromosomal region that has conserved synteny with HSA3 
      (PTR2q28, GGO2q28, PPY2q38 and MMU16B1). Using a gene-specific probe our results 
      are consistent with reports of the striking similarity of great ape and human 
      genomes as illustrated previously by chromosome painting.
CI  - Copyright (c) 2005 S. Karger AG, Basel.
FAU - Nanda, I
AU  - Nanda I
AD  - Department of Human Genetics, University of Wurzburg, Germany.
FAU - Kramer, F
AU  - Kramer F
FAU - Weber, B H F
AU  - Weber BH
FAU - Schempp, W
AU  - Schempp W
FAU - Schmid, M
AU  - Schmid M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Cytogenet Genome Res
JT  - Cytogenetic and genome research
JID - 101142708
RN  - 0 (CLDN1 protein, human)
RN  - 0 (Claudin-1)
RN  - 0 (Cldn1 protein, mouse)
RN  - 0 (Membrane Proteins)
SB  - IM
MH  - Animals
MH  - Chromosome Mapping/*methods
MH  - Chromosomes, Human, Pair 3/genetics
MH  - Chromosomes, Mammalian/genetics
MH  - Claudin-1
MH  - Gorilla gorilla/*genetics
MH  - Humans
MH  - Lymphocytes/chemistry/metabolism
MH  - Membrane Proteins/*genetics
MH  - Metaphase/genetics
MH  - Mice
MH  - Pan troglodytes/*genetics
MH  - Pongo pygmaeus/*genetics
MH  - Synteny/genetics
EDAT- 2004/11/17 09:00
MHDA- 2005/06/09 09:00
CRDT- 2004/11/17 09:00
PHST- 2003/10/01 00:00 [received]
PHST- 2004/01/13 00:00 [accepted]
PHST- 2004/11/17 09:00 [pubmed]
PHST- 2005/06/09 09:00 [medline]
PHST- 2004/11/17 09:00 [entrez]
AID - 80821 [pii]
AID - 10.1159/000080821 [doi]
PST - ppublish
SO  - Cytogenet Genome Res. 2005;108(1-3):229-33. doi: 10.1159/000080821.