PMID- 15546343
OWN - NLM
STAT- MEDLINE
DCOM- 20050419
LR  - 20171116
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 64
IP  - 6
DP  - 2004 Dec
TI  - Loss of heterozygosity in the HLA class I region in human pancreatic cancer.
PG  - 696-702
AB  - An altered human leukocyte antigen (HLA) class I expression constitutes an 
      important tumor-escape mechanism counteracting T-cell mediated immune responses. 
      We utilized the technique of microsatellite analysis to characterize the loss of 
      heterozygosity (LOH) in the HLA class I region in 24 samples of patients with 
      human ductal pancreatic carcinoma. The expression of HLA class I and the 
      infiltration by T cells were studied in parallel by standard 
      immunohistochemistry. The present study demonstrates LOH in the HLA class I 
      region in five patients with pancreatic carcinoma. Immunohistochemical analysis 
      showed that pancreatic carcinomas were frequently characterized by a total or 
      partial loss of expression in HLA class I antigen. The positive or negative LOH 
      status corresponded with the expression analysis in eight cases. Reduction of HLA 
      class I expression without LOH was found in 14 cases. Lymphocyte infiltration 
      with CD3+, CD4+, and CD8+ T cells did not show significant differences between 
      LOH-positive and LOH-negative tumors. In conclusion, LOH does not seem to be the 
      only factor for the reduced expression of HLA class I antigen as well as for the 
      T-cell infiltration in this type of tumor.
FAU - Ryschich, E
AU  - Ryschich E
AD  - Department of Surgery, University of Heidelberg, Heidelberg, Germany.
FAU - Cebotari, O
AU  - Cebotari O
FAU - Fabian, O V
AU  - Fabian OV
FAU - Autschbach, F
AU  - Autschbach F
FAU - Kleeff, J
AU  - Kleeff J
FAU - Friess, H
AU  - Friess H
FAU - Bierhaus, A
AU  - Bierhaus A
FAU - Buchler, M W
AU  - Buchler MW
FAU - Schmidt, J
AU  - Schmidt J
LA  - eng
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (CD3 Complex)
RN  - 0 (CD4 Antigens)
RN  - 0 (CD8 Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - CD3 Complex/immunology
MH  - CD4 Antigens/immunology
MH  - CD8 Antigens/immunology
MH  - Carcinoma, Pancreatic Ductal/*genetics/immunology/pathology
MH  - Chromosomes, Human, Pair 6/genetics
MH  - Histocompatibility Antigens Class I/*genetics/*immunology
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - *Loss of Heterozygosity
MH  - Lymphocytes, Tumor-Infiltrating/*immunology
MH  - Microsatellite Repeats
MH  - Pancreatic Neoplasms/genetics/immunology/pathology
MH  - T-Lymphocytes/*immunology
EDAT- 2004/11/18 09:00
MHDA- 2005/04/20 09:00
CRDT- 2004/11/18 09:00
PHST- 2004/11/18 09:00 [pubmed]
PHST- 2005/04/20 09:00 [medline]
PHST- 2004/11/18 09:00 [entrez]
AID - TAN324 [pii]
AID - 10.1111/j.1399-0039.2004.00324.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2004 Dec;64(6):696-702. doi: 10.1111/j.1399-0039.2004.00324.x.