PMID- 15546966
OWN - NLM
STAT- MEDLINE
DCOM- 20050303
LR  - 20071114
IS  - 1462-0324 (Print)
IS  - 1462-0324 (Linking)
VI  - 44
IP  - 1
DP  - 2005 Jan
TI  - Lack of association of matrix metalloproteinase 3 (MMP3) genotypes with 
      ankylosing spondylitis susceptibility and severity.
PG  - 55-60
AB  - OBJECTIVE: To study the linkage and association of ankylosing spondylitis (AS) 
      with genotypes for matrix metalloproteinase 3 (MMP3), a gene located at 
      chromosome 11q22.3 and lying within the 101-124 cM region observed in a recent 
      genome-wide scan as a region associated with AS susceptibility. METHODS: MMP3 
      genotypes were examined in 229 pedigrees with AS, 131 sporadic AS cases and 87 
      Caucasian controls. Eight single-nucleotide polymorphisms (SNPs) were selected 
      and genotyped using Taqman. Non-parametric linkage (NPL) analysis was conducted 
      between the eight MMP3 SNPs and AS using the NPL-all statistic and two-point 
      parametric linkage analysis using GeneHunter Plus. Unrelated AS cases and 
      controls were compared using chi2 statistics, and family-based controls using the 
      transmission disequilibrium test and pedigree disequilibrium test. RESULTS: None 
      of the eight MMP3 SNPs were significantly associated with AS, either using the 
      131 sporadic cases alone or in analyses which combined these cases with the 226 
      unrelated affected AS patients derived from the pedigrees. Analysis of linkage 
      disequilibrium (LD) demonstrated that seven of the eight SNPs studied were in 
      strong LD except for rs626750, which is about 6 kb upstream of the 5' end of the 
      gene. No significant linkage was observed using NPL and LODs in the families. No 
      association was seen of any of the MMP3 SNPs with disease severity (defined by 
      patient functioning), as measured either by the Bath Ankylosing Spondylitis 
      Functional Index or the modified Health Assessment Questionnaire. CONCLUSION: 
      These data suggest that MMP3 genotypes are not involved in AS susceptibility or 
      severity.
FAU - Jin, L
AU  - Jin L
AD  - University of Cincinnati, OH, USA.
FAU - Weisman, M
AU  - Weisman M
FAU - Zhang, G
AU  - Zhang G
FAU - Ward, M
AU  - Ward M
FAU - Luo, J
AU  - Luo J
FAU - Bruckel, J
AU  - Bruckel J
FAU - Inman, R
AU  - Inman R
FAU - Khan, M A
AU  - Khan MA
FAU - Schumacher, H R
AU  - Schumacher HR
FAU - Maksymowych, W P
AU  - Maksymowych WP
FAU - Mahowald, M
AU  - Mahowald M
FAU - Martin, T
AU  - Martin T
FAU - Rosenbaum, J T
AU  - Rosenbaum JT
FAU - Yu, D T Y
AU  - Yu DT
FAU - Stone, M
AU  - Stone M
FAU - Watson, J
AU  - Watson J
FAU - Dickman, E
AU  - Dickman E
FAU - Davis, J
AU  - Davis J
FAU - Reveille, J D
AU  - Reveille JD
LA  - eng
GR  - EY-13139/EY/NEI NIH HHS/United States
GR  - M01-RR02558/RR/NCRR NIH HHS/United States
GR  - R01-AR46208/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20041116
PL  - England
TA  - Rheumatology (Oxford)
JT  - Rheumatology (Oxford, England)
JID - 100883501
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Chromosomes, Human, Pair 11/genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Haplotypes
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Male
MH  - Matrix Metalloproteinase 3/*genetics
MH  - Middle Aged
MH  - Pedigree
MH  - Polymorphism, Single Nucleotide
MH  - Severity of Illness Index
MH  - Spondylitis, Ankylosing/*enzymology/*genetics
EDAT- 2004/11/18 09:00
MHDA- 2005/03/04 09:00
CRDT- 2004/11/18 09:00
PHST- 2004/11/18 09:00 [pubmed]
PHST- 2005/03/04 09:00 [medline]
PHST- 2004/11/18 09:00 [entrez]
AID - keh429 [pii]
AID - 10.1093/rheumatology/keh429 [doi]
PST - ppublish
SO  - Rheumatology (Oxford). 2005 Jan;44(1):55-60. doi: 10.1093/rheumatology/keh429. 
      Epub 2004 Nov 16.