PMID- 15547769
OWN - NLM
STAT- MEDLINE
DCOM- 20050323
LR  - 20061115
IS  - 1093-5266 (Print)
IS  - 1093-5266 (Linking)
VI  - 7
IP  - 5
DP  - 2004 Sep-Oct
TI  - Characterization of inflammation in syphilitic villitis and in villitis of 
      unknown etiology.
PG  - 453-8; discussion 421
AB  - Chronic villitis is a histologic diagnosis that may be either associated with 
      infection, or termed villitis of undetermined etiology (VUE). The lymphocytic 
      infiltrate in VUE has been reported to consist of maternal lymphocytes, but the 
      origin of the lymphocytic infiltrate in infectious villitis has not been 
      identified. The purpose of our study was to compare the maternal vs. fetal origin 
      of the infiltrating lymphocytes in VUE and syphilitic villitis, and to expand the 
      immunophenotypic data provided by previous studies. Paraffin-embedded placentas 
      from four males with VUE and two males with syphilitic villitis were subjected to 
      fluorescence in situ hybridization (FISH) for the X and Y chromosomes. Serial 
      sections were stained with antibodies to CD3, CD4, CD8, CD68, HLA-DR, and CD20. 
      Quantitation of the relative number of cells marking with each antibody was done 
      for four villi in each slide. CD3 lymphocytes predominated in both VUE and 
      syphilitic villitis, with slightly more CD8 cells compared to CD4 cells. CD68 and 
      HLA-DR positive cells were as frequent as CD3 cells, and B-lymphocytes were rare. 
      Maternal cells were the predominant intravillous population in both VUE and 
      syphilitic villitis, and neutrophils in syphilitic villitis were also maternal. 
      These data indicate that the immune response in both syphilitic villitis and VUE 
      is similar, raising the possibility of a similar immunopathogenetic pathway.
FAU - Kapur, Payal
AU  - Kapur P
AD  - Department of Pathology, The University of Texas Southwestern Medical School, 
      Dallas, TX, USA.
FAU - Rakheja, Dinesh
AU  - Rakheja D
FAU - Gomez, Ana M
AU  - Gomez AM
FAU - Sheffield, Jeanne
AU  - Sheffield J
FAU - Sanchez, Pablo
AU  - Sanchez P
FAU - Rogers, Beverly Barton
AU  - Rogers BB
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20040730
PL  - United States
TA  - Pediatr Dev Pathol
JT  - Pediatric and developmental pathology : the official journal of the Society for 
      Pediatric Pathology and the Paediatric Pathology Society
JID - 9809673
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - B-Lymphocytes/immunology
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - CD8-Positive T-Lymphocytes/immunology
MH  - Child
MH  - Chorionic Villi/immunology/*pathology
MH  - Female
MH  - Fetus
MH  - Humans
MH  - Immunohistochemistry
MH  - Immunophenotyping
MH  - In Situ Hybridization, Fluorescence
MH  - Inflammation/*etiology/immunology/pathology
MH  - Macrophages/immunology
MH  - Male
MH  - Placenta Diseases/*etiology/immunology/pathology
MH  - Pregnancy
MH  - Syphilis/*complications/immunology/pathology
EDAT- 2004/11/18 09:00
MHDA- 2005/03/24 09:00
CRDT- 2004/11/18 09:00
PHST- 2003/12/19 00:00 [received]
PHST- 2004/04/21 00:00 [accepted]
PHST- 2004/11/18 09:00 [pubmed]
PHST- 2005/03/24 09:00 [medline]
PHST- 2004/11/18 09:00 [entrez]
AID - 10.1007/s10024-004-2124-3 [doi]
PST - ppublish
SO  - Pediatr Dev Pathol. 2004 Sep-Oct;7(5):453-8; discussion 421. doi: 
      10.1007/s10024-004-2124-3. Epub 2004 Jul 30.