PMID- 15547808
OWN - NLM
STAT- MEDLINE
DCOM- 20050401
LR  - 20190917
IS  - 0196-0709 (Print)
IS  - 0196-0709 (Linking)
VI  - 25
IP  - 6
DP  - 2004 Nov-Dec
TI  - The role of viruses in idiopathic peripheral facial palsy and cellular immune 
      response.
PG  - 401-6
AB  - PURPOSE: The purpose of this study is to investigate the role of viruses on the 
      idiopathic peripheral facial palsy and show the interaction of immune system. 
      MATERIALS AND METHODS: The levels of immunoglobulin (Ig) G and IgM antibodies 
      against to varicella-zoster virus (VZV), herpes simplex virus (HSV), 
      cytomegalovirus (CMV), Ebstein-Barr virus (EBV), and mumps virus in venous blood 
      taken from patients in the amount of 10 mL have been investigated by 
      enzyme-linked immunosorbent assay method. Tumor necrosis factor-alpha 
      (TNF-alpha), interferon-gamma (IFN-gamma), and transforming growth factor-beta 
      (TGF-beta) were also examined. Of lymphocyte subpopulation, antibodies of CD3(+), 
      CD4(+), CD8(+), CD19(+), and CD16(+) plus 56(+) were analyzed. RESULTS: Ten of 
      the patients had HSV-1 IgG; 1 of the patients IgM, 5 of the patients EBV IgG, 6 
      of the patients VZV IgG, 1 of the patients IgM, 9 of the patients mumps IgG, 1 of 
      the patients IgM, and finally in 7 of the patients CMV IgG antibodies were 
      obtained. It was found that CD4(+) cell and ratio of CD4(+)/CD8(+) lower and the 
      percentage of the CD8(+) and CD16(+) plus 56(+) cells higher compared with the 
      control group (P < .05). The levels of TNF-alpha were lower, whereas IFN-gamma 
      and TGF-beta1 were higher. CONCLUSION: It may be concluded from these results 
      that VZV, HSV-1, CMV, EBV, and mumps virus play a significant role in the 
      etiology of idiopathic peripheral facial palsy and activate the cellular 
      immunity.
FAU - Kaygusuz, Irfan
AU  - Kaygusuz I
AD  - Department of Otorhinolaryngology, Firat University Medical Center, 23200 Elazig, 
      Turkey. kaygusuz_67@yahoo.com
FAU - Godekmerdan, Ahmet
AU  - Godekmerdan A
FAU - Keles, Erol
AU  - Keles E
FAU - Karlidag, Turgut
AU  - Karlidag T
FAU - Yalcin, Sinasi
AU  - Yalcin S
FAU - Yildiz, Mucahit
AU  - Yildiz M
FAU - Tazegul, Ayca
AU  - Tazegul A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Otolaryngol
JT  - American journal of otolaryngology
JID - 8000029
RN  - 0 (Antibodies, Viral)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
SB  - IM
MH  - Adult
MH  - Antibodies, Viral/*analysis
MH  - Cytomegalovirus/immunology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Facial Paralysis/immunology/*virology
MH  - Female
MH  - Herpes Simplex/immunology
MH  - Herpesvirus 3, Human/immunology
MH  - Herpesvirus 4, Human/immunology
MH  - Humans
MH  - Immunity, Cellular/*physiology
MH  - Immunoglobulin G/immunology
MH  - Immunoglobulin M/immunology
MH  - Male
MH  - Mumps virus/immunology
EDAT- 2004/11/18 09:00
MHDA- 2005/04/02 09:00
CRDT- 2004/11/18 09:00
PHST- 2004/11/18 09:00 [pubmed]
PHST- 2005/04/02 09:00 [medline]
PHST- 2004/11/18 09:00 [entrez]
AID - S0196070904000742 [pii]
AID - 10.1016/j.amjoto.2004.04.011 [doi]
PST - ppublish
SO  - Am J Otolaryngol. 2004 Nov-Dec;25(6):401-6. doi: 10.1016/j.amjoto.2004.04.011.