PMID- 15548266
OWN - NLM
STAT- MEDLINE
DCOM- 20050329
LR  - 20111117
IS  - 0960-7420 (Print)
IS  - 0960-7420 (Linking)
VI  - 31
IP  - 6
DP  - 2004 Dec
TI  - Analysis of human leukocyte antigen (HLA)-G polymorphism in normal women and in 
      women with recurrent spontaneous abortions.
PG  - 275-8
AB  - Human leukocyte antigen (HLA)-G is a non-classical class I antigen. It has 
      limited expression, but is high at the foetomaternal interface. This unique 
      expression pattern of HLA-G suggests that it might be important for survival of 
      the foetus during pregnancy. In the present study, 120 women with recurrent 
      spontaneous abortions (RSA) and 120 fertile control women were genotyped for the 
      HLA-G locus. This is the first report describing HLA-G polymorphism in normal 
      fertile and RSA women from India. The allele HLA-G*010103 was higher in women 
      with recurrent foetal losses. Interestingly, the HLA-G*010105 and G*010108 
      alleles were totally absent in normal fertile women but present in RSA women with 
      frequencies of 1.7% and 0.4%, respectively. Allele G*010107 was absent in both 
      the groups. The frequency of the null allele G*0105N was high (13.8%) in our 
      population as compared to other world populations. Our data support the 
      hypothesis that HLA-G polymorphism may contribute to recurrent foetal loss.
FAU - Abbas, A
AU  - Abbas A
AD  - Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical 
      Sciences, Lucknow, India.
FAU - Tripathi, P
AU  - Tripathi P
FAU - Naik, S
AU  - Naik S
FAU - Agrawal, S
AU  - Agrawal S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Immunogenet
JT  - European journal of immunogenetics : official journal of the British Society for 
      Histocompatibility and Immunogenetics
JID - 9106962
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Abortion, Habitual/genetics/*immunology
MH  - Female
MH  - Gene Frequency
MH  - HLA Antigens/*genetics/immunology
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*genetics/immunology
MH  - Humans
MH  - Polymerase Chain Reaction
MH  - Pregnancy
EDAT- 2004/11/19 09:00
MHDA- 2005/03/30 09:00
CRDT- 2004/11/19 09:00
PHST- 2004/11/19 09:00 [pubmed]
PHST- 2005/03/30 09:00 [medline]
PHST- 2004/11/19 09:00 [entrez]
AID - EJI487 [pii]
AID - 10.1111/j.1365-2370.2004.00487.x [doi]
PST - ppublish
SO  - Eur J Immunogenet. 2004 Dec;31(6):275-8. doi: 10.1111/j.1365-2370.2004.00487.x.