PMID- 15548372
OWN - NLM
STAT- MEDLINE
DCOM- 20050421
LR  - 20181113
IS  - 1522-8002 (Print)
IS  - 1476-5586 (Electronic)
IS  - 1476-5586 (Linking)
VI  - 6
IP  - 5
DP  - 2004 Sep-Oct
TI  - Genomic profiles in stage I primary non small cell lung cancer using comparative 
      genomic hybridization analysis of cDNA microarrays.
PG  - 623-35
AB  - To investigate the genomic aberrations that are involved in lung tumorigenesis 
      and therefore may be developed as biomarkers for lung cancer diagnosis, we 
      characterized the genomic copy number changes associated with individual genes in 
      14 tumors from patients with primary non small cell lung cancer (NSCLC). Six 
      squamous cell carcinomas (SQCAs) and eight adenocarcinomas (ADCAs) were examined 
      by high-resolution comparative genomic hybridization (CGH) analysis of cDNA 
      microarray. The SQCAs and ADCAs shared common frequency distributions of 
      recurrent genomic gains of 63 genes and losses of 72 genes. Cluster analysis 
      using 57 genes defined the genomic differences between these two major histologic 
      types of NSCLC. Genomic aberrations from a set of 18 genes showed distinct 
      difference of primary ADCAs from their paired normal lung tissues. The genomic 
      copy number of four genes was validated by fluorescence in situ hybridization of 
      32 primary NSCLC tumors, including those used for cDNA microarray CGH analysis; a 
      strong correlation with cDNA microarray CGH data emerged. The identified genomic 
      aberrations may be involved in the initiation and progression of lung 
      tumorigenesis and, most importantly, may be developed as new biomarkers for the 
      early detection and classification of lung cancer.
FAU - Jiang, Feng
AU  - Jiang F
AD  - Department of Pathology, The University of Texas M.D. Anderson Cancer Center, 
      Houston, TX, USA. fjiang@mail.mdanderson.org
FAU - Yin, Zhengnan
AU  - Yin Z
FAU - Caraway, Nancy P
AU  - Caraway NP
FAU - Li, Ruiyun
AU  - Li R
FAU - Katz, Ruth L
AU  - Katz RL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neoplasia
JT  - Neoplasia (New York, N.Y.)
JID - 100886622
RN  - 0 (S-Phase Kinase-Associated Proteins)
SB  - IM
MH  - Adenocarcinoma/diagnosis/genetics
MH  - Carcinoma, Non-Small-Cell Lung/diagnosis/*genetics
MH  - Carcinoma, Squamous Cell/diagnosis/genetics
MH  - *Chromosome Aberrations
MH  - *Gene Dosage
MH  - Gene Expression Profiling
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lung Neoplasms/diagnosis/*genetics
MH  - Neoplasm Staging
MH  - Oligonucleotide Array Sequence Analysis
MH  - S-Phase Kinase-Associated Proteins/genetics
PMC - PMC1531667
EDAT- 2004/11/19 09:00
MHDA- 2005/04/22 09:00
PMCR- 2004/09/01
CRDT- 2004/11/19 09:00
PHST- 2004/11/19 09:00 [pubmed]
PHST- 2005/04/22 09:00 [medline]
PHST- 2004/11/19 09:00 [entrez]
PHST- 2004/09/01 00:00 [pmc-release]
AID - 04142 [pii]
AID - 10.1593/neo.04142 [doi]
PST - ppublish
SO  - Neoplasia. 2004 Sep-Oct;6(5):623-35. doi: 10.1593/neo.04142.