PMID- 15548422
OWN - NLM
STAT- MEDLINE
DCOM- 20050106
LR  - 20171116
IS  - 0074-7696 (Print)
IS  - 0074-7696 (Linking)
VI  - 241
DP  - 2004
TI  - Insect basic leucine zipper proteins and their role in cyclic AMP-dependent 
      regulation of gene expression.
PG  - 277-309
AB  - The cAMP-protein kinase A (PKA) pathway is an important intracellular signal 
      transduction cascade that can be activated by a large variety of stimuli. 
      Activation or inhibition of this pathway will ultimately affect the 
      transcriptional regulation of various genes through distinct responsive sites. In 
      vertebrates, the best- characterized nuclear targets of PKA are the cyclic AMP 
      response element-binding (CREB) proteins. It is now well established that CREB is 
      not only regulated by PKA, but many other kinases can exert an effect as well. 
      Since CREB-like proteins were also discovered in invertebrates, several studies 
      unraveling their physiological functions in this category of metazoans have been 
      performed. This review will mainly focus on the presence and regulation of CREB 
      proteins in insects. Differences in transcriptional responses to the PKA pathway 
      and other CREB-regulating stimuli between cells, tissues, and even organisms can 
      be partially attributed to the presence of different CREB isoforms. In addition, 
      the regulation of CREB appears to show some important differences between insects 
      and vertebrates. Since CREB is a basic leucine zipper (bZip) protein, other 
      insect members of this important family of transcriptional regulators will be 
      briefly discussed as well.
FAU - Poels, Jeroen
AU  - Poels J
AD  - Laboratory for Developmental Physiology, Genomics and Proteomics, Catholic 
      University Leuven, B-3000 Leuven, Belgium.
FAU - Vanden Broeck, Jozef
AU  - Vanden Broeck J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Int Rev Cytol
JT  - International review of cytology
JID - 2985180R
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Protein Isoforms)
RN  - E0399OZS9N (Cyclic AMP)
RN  - EC 2.7.11.11 (Cyclic AMP-Dependent Protein Kinases)
SB  - IM
MH  - Animals
MH  - Cyclic AMP/*metabolism
MH  - Cyclic AMP Response Element-Binding Protein/genetics/*metabolism
MH  - Cyclic AMP-Dependent Protein Kinases/metabolism
MH  - Gene Expression Regulation/genetics/*physiology
MH  - Insecta/genetics/*metabolism
MH  - Leucine Zippers/*genetics
MH  - Protein Isoforms/metabolism
MH  - Species Specificity
RF  - 179
EDAT- 2004/11/19 09:00
MHDA- 2005/01/07 09:00
CRDT- 2004/11/19 09:00
PHST- 2004/11/19 09:00 [pubmed]
PHST- 2005/01/07 09:00 [medline]
PHST- 2004/11/19 09:00 [entrez]
AID - S0074769604410055 [pii]
AID - 10.1016/S0074-7696(04)41005-5 [doi]
PST - ppublish
SO  - Int Rev Cytol. 2004;241:277-309. doi: 10.1016/S0074-7696(04)41005-5.