PMID- 1554865
OWN - NLM
STAT- MEDLINE
DCOM- 19920507
LR  - 20180215
IS  - 1018-1172 (Print)
IS  - 1018-1172 (Linking)
VI  - 29
IP  - 1
DP  - 1992 Jan-Feb
TI  - Vascular, ganglia and cardiac catecholamine disposition in the spontaneously 
      hypertensive rat and in the stroke-prone spontaneously hypertensive rat.
PG  - 8-12
AB  - We have examined the disposition of catecholamines in cardiac tissue, mesenteric 
      arteries and ganglia from normotensive Wistar-Kyoto rats (WKY), spontaneously 
      hypertensive rats (SHR) and stroke-prone spontaneously hypertensive rats 
      (SHR-SP). The norepinephrine (NE) contents of mesenteric arteries from all three 
      strains of rats adhered to a pattern which was characterized by the largest 
      concentrations of the catecholamine in arteries from SHR and SHR-SP rats, and the 
      smallest values present in mesenteric arteries from WKY rats. This pattern of NE 
      disposition was not present in either ganglia or cardiac tissue from the three 
      strains of rats. The results highlight two features of the hypernoradrenergic 
      hypothesis in the SHR. Firstly, the enhanced NE contents observed in the blood 
      vessels of the two hypertensive strains are not consistently increased in 
      sympathetic cell bodies or cardiac tissue. Secondly, the significantly enhanced 
      concentrations of NE in the vasculature parallel the elevated direct arterial 
      blood pressure in the two strains of hypertensive rat when compared with the 
      normotensive strain.
FAU - Mano, M
AU  - Mano M
AD  - CSIRO Division of Human Nutrition, Hypertension Research Unit, Adelaide, 
      Australia.
FAU - Jeffreson, S
AU  - Jeffreson S
FAU - Head, R J
AU  - Head RJ
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - J Vasc Res
JT  - Journal of vascular research
JID - 9206092
RN  - VTD58H1Z2X (Dopamine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Animals
MH  - Cerebrovascular Disorders/*metabolism
MH  - Dopamine/*metabolism
MH  - Ganglia, Sympathetic/*metabolism
MH  - Hypertension/*metabolism
MH  - Male
MH  - Mesenteric Arteries/*metabolism
MH  - Myocardium/*metabolism
MH  - Norepinephrine/*metabolism
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
AID - 10.1159/000158925 [doi]
PST - ppublish
SO  - J Vasc Res. 1992 Jan-Feb;29(1):8-12. doi: 10.1159/000158925.