PMID- 15548995
OWN - NLM
STAT- MEDLINE
DCOM- 20050331
LR  - 20210102
IS  - 1065-6251 (Print)
IS  - 1065-6251 (Linking)
VI  - 11
IP  - 6
DP  - 2004 Nov
TI  - Interleukin-18: recent advances.
PG  - 405-10
AB  - PURPOSE OF REVIEW: Interleukin-18 (IL-18) has potent immunomodulatory effects. It 
      is the only cytokine with a unique capacity to induce T helper 1 or T helper 2 
      polarization, depending on the immunologic context. Serum levels of IL-18 are 
      increased in many human diseases and it has been implicated in the pathogenesis 
      of several immune-mediated processes. Some of the recent key advances in the 
      immunobiology of IL-18 are discussed in this review. RECENT FINDINGS: Recent data 
      from several laboratories have shed light on the structure of IL-18; the 
      signaling cascades that are initiated; and its role on modulating T cells, 
      dendritic cells, and natural killer cell function. Several new reports have 
      expanded and delineated the role of IL-18 in a multitude of diseases, but only 
      recent advances in the role of IL-18 in three disease processes (acute 
      graft-versus-host disease, insulin-dependent diabetes, and sepsis), where it 
      appears to play paradoxic roles are discussed. SUMMARY: Although emerging data 
      shed more light on the complex role of IL-18 in immune reactions, they also pose 
      more questions. Given the pleiotropic, complex, and at times paradoxic effects of 
      IL-18 in various disease processes, better understanding of its immunobiology 
      might lead to the development of IL-18 and/or its antagonists as therapeutic 
      agents against immune-mediated diseases.
FAU - Reddy, Pavan
AU  - Reddy P
AD  - Department of Internal Medicine, University of Michigan Comprehensive Cancer 
      Center, Ann Arbor, Michigan 48109-0942, USA. reddypr@umich.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Hematol
JT  - Current opinion in hematology
JID - 9430802
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus, Type 1/immunology
MH  - Humans
MH  - Inflammation/immunology
MH  - Interleukin-18/*immunology
MH  - Sepsis/immunology
MH  - Signal Transduction/*immunology
MH  - Th1 Cells/*immunology
MH  - Th2 Cells/*immunology
RF  - 81
EDAT- 2004/11/19 09:00
MHDA- 2005/04/01 09:00
CRDT- 2004/11/19 09:00
PHST- 2004/11/19 09:00 [pubmed]
PHST- 2005/04/01 09:00 [medline]
PHST- 2004/11/19 09:00 [entrez]
AID - 00062752-200411000-00007 [pii]
AID - 10.1097/01.moh.0000141926.95319.42 [doi]
PST - ppublish
SO  - Curr Opin Hematol. 2004 Nov;11(6):405-10. doi: 
      10.1097/01.moh.0000141926.95319.42.