PMID- 15551097
OWN - NLM
STAT- MEDLINE
DCOM- 20050531
LR  - 20171116
IS  - 0939-5555 (Print)
IS  - 0939-5555 (Linking)
VI  - 84
IP  - 4
DP  - 2005 Apr
TI  - Pericentric chromosome 8 inversion associated with the 5'RUNX1/3'CBFA2T1 gene in 
      acute myeloid leukemia cases.
PG  - 245-9
AB  - In the present paper we report pericentric chromosome 8 inversions in two (2.4%) 
      of 82 acute myeloid leukemia (AML) cases characterized by the 5'RUNX1/3'CBFA2T1 
      fusion gene. Molecular cytogenetic characterization was achieved using 
      appropriate bacterial artificial chromosome (BAC) and P1 artificial chromosome 
      (PAC) probes in fluorescence in situ hybridization (FISH) experiments. In these 
      two cases the fusion gene was detected on the der(8) short arm, resulting from a 
      pericentric chromosome 8 inversion followed by a t(8;21) rearrangement. These 
      results suggest that heterogeneous mechanisms can lead to the generation of the 
      5'RUNX1/3'CBFA2T1chimeric gene.
FAU - Anelli, L
AU  - Anelli L
AD  - Department of Hematology, University of Foggia, Viale Pinto 1, 71100 Foggia, 
      Italy.
FAU - Albano, F
AU  - Albano F
FAU - Zagaria, A
AU  - Zagaria A
FAU - Liso, A
AU  - Liso A
FAU - Cuneo, A
AU  - Cuneo A
FAU - Mancini, M
AU  - Mancini M
FAU - Liso, V
AU  - Liso V
FAU - Rocchi, M
AU  - Rocchi M
FAU - Specchia, G
AU  - Specchia G
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20041116
PL  - Germany
TA  - Ann Hematol
JT  - Annals of hematology
JID - 9107334
RN  - 0 (Core Binding Factor Alpha 2 Subunit)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (RUNX1 Translocation Partner 1 Protein)
RN  - 0 (RUNX1 protein, human)
RN  - 0 (RUNX1T1 protein, human)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - *Chromosome Inversion
MH  - *Chromosomes, Human, Pair 8
MH  - Core Binding Factor Alpha 2 Subunit
MH  - DNA-Binding Proteins/*genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Myeloid/*genetics
MH  - Male
MH  - Middle Aged
MH  - Oncogene Proteins, Fusion/genetics
MH  - Proto-Oncogene Proteins/*genetics
MH  - RUNX1 Translocation Partner 1 Protein
MH  - Transcription Factors/*genetics
EDAT- 2004/11/20 09:00
MHDA- 2005/06/01 09:00
CRDT- 2004/11/20 09:00
PHST- 2004/08/06 00:00 [received]
PHST- 2004/09/26 00:00 [accepted]
PHST- 2004/11/20 09:00 [pubmed]
PHST- 2005/06/01 09:00 [medline]
PHST- 2004/11/20 09:00 [entrez]
AID - 10.1007/s00277-004-0960-x [doi]
PST - ppublish
SO  - Ann Hematol. 2005 Apr;84(4):245-9. doi: 10.1007/s00277-004-0960-x. Epub 2004 Nov 
      16.