PMID- 15556682
OWN - NLM
STAT- MEDLINE
DCOM- 20051017
LR  - 20081121
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 65
IP  - 11
DP  - 2004 Nov
TI  - CD25+ regulatory cells from HLA-DQ8 transgenic mice are capable of modulating 
      collagen-induced arthritis.
PG  - 1319-27
AB  - In the last decade, CD4+CD25+ T regulatory cells have been implicated in the 
      protection against autoimmune diseases. The human DQ8 major histocompatibility 
      complex (MHC) class II molecule is associated with rheumatoid arthritis (RA) and 
      various other autoimmune diseases in humans. The human leukocyte antigen 
      (HLA)-DQ8 transgenic mouse, containing the human DQ8 MHC class II molecule, is 
      predisposed toward collagen-induced arthritis. However, the biologic pathways 
      responsible for DQ8-associated autoimmunity have yet to be defined, including 
      possible defects in the CD4+CD25+ T regulatory cell compartment. To explore this 
      concept, we examined the suppressive capacity of CD4+CD25+ T regulatory cells 
      from DQ8 transgenic mice in vitro and, using CD25-specific depleting antibodies, 
      investigated their influence on collagen-induced arthritis in vivo. CD4+CD25+ T 
      regulatory cells isolated from DQ8 transgenic mice were found to be sufficient 
      suppressors of splenocyte proliferation and interferon (INF)-gamma production. 
      Furthermore, depletion of these cells before immunization led to significant 
      increases in arthritis severity, collagen-specific antibodies, and INF-gamma 
      production. These results indicate that HLA-DQ8 mice contain naturally occurring 
      CD25+ regulatory cells that modulate collagen-induced arthritis and imply that 
      DQ8 expression does not hinder the development of CD25+ T regulatory cells.
FAU - Morgan, Mary E
AU  - Morgan ME
AD  - Department of Rheumatology, Leiden University Medical Center, Leiden, The 
      Netherlands. m.morgan@ncmls.kun.nl
FAU - Witteveen, Hendrik J
AU  - Witteveen HJ
FAU - Sutmuller, Roger P M
AU  - Sutmuller RP
FAU - de Vries, Rene R P
AU  - de Vries RR
FAU - Toes, Rene E M
AU  - Toes RE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Antibodies)
RN  - 0 (Collagen Type II)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ8 antigen)
RN  - 0 (Receptors, Interleukin-2)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Antibodies/blood/immunology
MH  - Arthritis, Experimental/etiology/*immunology
MH  - CD4-Positive T-Lymphocytes/cytology/*immunology
MH  - Collagen Type II/immunology
MH  - HLA-DQ Antigens/*genetics/immunology
MH  - Humans
MH  - Immune Tolerance/immunology
MH  - Interferon-gamma/metabolism
MH  - Lymphocyte Activation/immunology
MH  - Lymphocyte Depletion
MH  - Male
MH  - Mice
MH  - Mice, Inbred DBA
MH  - Mice, Transgenic
MH  - Receptors, Interleukin-2/*immunology
MH  - T-Lymphocytes/metabolism
EDAT- 2004/11/24 09:00
MHDA- 2005/10/18 09:00
CRDT- 2004/11/24 09:00
PHST- 2004/04/08 00:00 [received]
PHST- 2004/06/24 00:00 [revised]
PHST- 2004/06/30 00:00 [accepted]
PHST- 2004/11/24 09:00 [pubmed]
PHST- 2005/10/18 09:00 [medline]
PHST- 2004/11/24 09:00 [entrez]
AID - S0198-8859(04)00158-2 [pii]
AID - 10.1016/j.humimm.2004.06.011 [doi]
PST - ppublish
SO  - Hum Immunol. 2004 Nov;65(11):1319-27. doi: 10.1016/j.humimm.2004.06.011.