PMID- 1555872
OWN - NLM
STAT- MEDLINE
DCOM- 19920506
LR  - 20221207
IS  - 0194-911X (Print)
IS  - 0194-911X (Linking)
VI  - 19
IP  - 4
DP  - 1992 Apr
TI  - Essential hypertension and histocompatibility antigens. An association study.
PG  - 400-2
AB  - Data from a previous study concerning the distribution of human leukocyte antigen 
      (HLA) haplotypes in siblings with essential hypertension suggested that at least 
      one of the genes responsible for the genetic susceptibility to this disease is 
      located in or near the HLA complex. The objective of the present study was to 
      investigate if a given HLA-A, B, or DR gene could represent a marker for 
      susceptibility to essential hypertension at the population level. Thus, the 
      frequencies of HLA antigens were determined in Caucasian patients with essential 
      hypertension (HLA-A and B antigens were determined in 89 cases, 85 of which were 
      also typed for HLA-DR antigens). The results showed an increased frequency (p = 
      0.00064) of HLA-DR4, which was present in 34% of the patients and in 16% of local 
      ethnically matched control subjects. We conclude that HLA-DR4 may represent a 
      marker for susceptibility to essential hypertension in the Brazilian Caucasian 
      population.
FAU - Gerbase-DeLima, M
AU  - Gerbase-DeLima M
AD  - Escola Paulista de Medicina, Hospital das Clinicas, Faculdade de Medicina, 
      Universidade de Sao Paulo, Brazil.
FAU - Ladalardo, M A
AU  - Ladalardo MA
FAU - DeLima, J J
AU  - DeLima JJ
FAU - Silva, H B
AU  - Silva HB
FAU - Bellotti, G
AU  - Bellotti G
FAU - Pileggi, F
AU  - Pileggi F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hypertension
JT  - Hypertension (Dallas, Tex. : 1979)
JID - 7906255
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR4 Antigen)
SB  - IM
CIN - Hypertension. 1992 Nov;20(5):710-1. PMID: 1428119
MH  - Brazil
MH  - Female
MH  - HLA-A Antigens/*analysis
MH  - HLA-B Antigens/*analysis
MH  - HLA-DR4 Antigen/*analysis
MH  - Humans
MH  - Hypertension/*immunology
MH  - Male
MH  - White People
EDAT- 1992/04/01 00:00
MHDA- 1992/04/01 00:01
CRDT- 1992/04/01 00:00
PHST- 1992/04/01 00:00 [pubmed]
PHST- 1992/04/01 00:01 [medline]
PHST- 1992/04/01 00:00 [entrez]
AID - 10.1161/01.hyp.19.4.400 [doi]
PST - ppublish
SO  - Hypertension. 1992 Apr;19(4):400-2. doi: 10.1161/01.hyp.19.4.400.