PMID- 15559001
OWN - NLM
STAT- MEDLINE
DCOM- 20050428
LR  - 20071115
IS  - 0095-6562 (Print)
IS  - 0095-6562 (Linking)
VI  - 75
IP  - 11
DP  - 2004 Nov
TI  - Seizure incidence in 80,000 patient treatments with hyperbaric oxygen.
PG  - 992-4
AB  - INTRODUCTION: Hyperbaric oxygen treatment (HBOT) involves some risk of central 
      nervous system (CNS) oxygen toxicity, which may be revealed by various signs and 
      symptoms including seizures in patients breathing O2 at pressures of 2 ATA or 
      higher. The aim of this study was to determine the incidence of such seizures in 
      the Underwater and Hyperbaric Medicine Departments of two university hospitals. 
      METHODS: We retrospectively evaluated 80,679 patient-treatments for 9 clinical 
      indications to determine the incidence of seizures attributable to CNS O2 
      toxicity. Because different protocols were used for HBOT, the treatments were 
      studied in four groups according to the chamber type used and the medical 
      facility at which it was located. RESULTS: Only 2 seizures were documented, 
      yielding an incidence of 2.4 per 100,000 patient-treatments. Both cases occurred 
      in a multiplace chamber pressurized to 2.4 ATA with O2 delivered by mask for 
      three x 30 min with 5-min air breaks. DISCUSSION: The seizure incidence reported 
      here is lower than other studies published in the literature. The delivery of O2 
      by mask rather than hood may be a factor. Nevertheless, it appears that the risk 
      of seizures due to CNS O2 toxicity during HBOT is very low as long as appropriate 
      exclusion criteria and treatment profiles are used.
FAU - Yildiz, Senol
AU  - Yildiz S
AD  - Gulhane Military Medical Academy, Haydarpasa Training Hospital, Department of 
      Underwater and Hyperbaric Medicine, 81100 Kadikoy-Istanbul, Turkey. 
      syildiz@gata.edu.tr
FAU - Aktas, Samil
AU  - Aktas S
FAU - Cimsit, Maide
AU  - Cimsit M
FAU - Ay, Hakan
AU  - Ay H
FAU - Togrol, Erdem
AU  - Togrol E
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Aviat Space Environ Med
JT  - Aviation, space, and environmental medicine
JID - 7501714
SB  - IM
CIN - Aviat Space Environ Med. 2004 Nov;75(11):995-6. PMID: 15559002
MH  - Adolescent
MH  - Adult
MH  - Databases as Topic
MH  - Hospitals, University
MH  - Humans
MH  - Hyperbaric Oxygenation/*adverse effects
MH  - Incidence
MH  - Male
MH  - Retrospective Studies
MH  - Seizures/*epidemiology/etiology
MH  - Turkey/epidemiology
EDAT- 2004/11/24 09:00
MHDA- 2005/04/29 09:00
CRDT- 2004/11/24 09:00
PHST- 2004/11/24 09:00 [pubmed]
PHST- 2005/04/29 09:00 [medline]
PHST- 2004/11/24 09:00 [entrez]
PST - ppublish
SO  - Aviat Space Environ Med. 2004 Nov;75(11):992-4.