PMID- 1555996
OWN - NLM
STAT- MEDLINE
DCOM- 19920506
LR  - 20190509
IS  - 0910-5050 (Print)
IS  - 1876-4673 (Electronic)
IS  - 0910-5050 (Linking)
VI  - 83
IP  - 2
DP  - 1992 Feb
TI  - High susceptibility of analbuminemic rats to neurogenic tumor induction by 
      transplacental administration of N-ethyl-N-nitrosourea.
PG  - 146-52
AB  - The susceptibilities of Nagase analbuminemic rats (NAR) and control 
      Sprague-Dawley rats (SDR) to N-ethyl-N-nitrosourea (ENU) were compared. In 
      Experiment I, the rats were given daily subcutaneous injections of 10 mg/kg of 
      ENU for a week from 4 weeks of age. In Experiment II, mother rats were given a 
      single subcutaneous injection of 60 mg/kg of ENU on day 17 of pregnancy and tumor 
      development in their offspring was examined. In Experiment I, the incidence of 
      neurogenic tumors was slightly, but not significantly, higher in NAR than in 
      control rats. In Experiment II, the incidence of total tumors including 
      neurogenic tumors was significantly higher in NAR (40/43, 93.0%) than in SDR 
      (13/61, 21.3%). NAR showed particularly high susceptibility to induction of 
      neurogenic tumors (34/43, 79.1%) and renal tumors (15/43, 34.9%). In an attempt 
      to elucidate the underlying mechanisms of the increased susceptibility of NAR to 
      ENU, O6-ethylguanine, a major premutagenic ethylated DNA adduct, was quantitated 
      in fetal brain DNA of NAR and SDR after a pulse exposure to 60 mg/kg ENU. No 
      significant difference in the initial formation or subsequent repair of 
      O6-ethylguanine was observed in the two strains, indicating that abnormality at 
      some later stage(s) of chemical carcinogenesis may lead to the increased 
      susceptibility of NAR to induction of neurogenic tumors.
FAU - Usuki, S
AU  - Usuki S
AD  - Department of Biochemistry, Sasaki Institute, Tokyo.
FAU - Maekawa, A
AU  - Maekawa A
FAU - Kang, H
AU  - Kang H
FAU - Shumiya, S
AU  - Shumiya S
FAU - Nagase, S
AU  - Nagase S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Jpn J Cancer Res
JT  - Japanese journal of cancer research : Gann
JID - 8509412
RN  - 0 (DNA, Neoplasm)
RN  - 5Z93L87A1R (Guanine)
RN  - P8M1T4190R (Ethylnitrosourea)
SB  - IM
MH  - Animals
MH  - Brain Neoplasms/*chemically induced/pathology
MH  - DNA, Neoplasm/analysis
MH  - Disease Susceptibility
MH  - Ethylnitrosourea/*administration & dosage
MH  - Female
MH  - Guanine/analogs & derivatives/analysis
MH  - Injections, Subcutaneous
MH  - Male
MH  - Placenta
MH  - Pregnancy
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Spinal Cord Neoplasms/*chemically induced/pathology
PMC - PMC5918778
EDAT- 1992/02/01 00:00
MHDA- 1992/02/01 00:01
PMCR- 1992/02/01
CRDT- 1992/02/01 00:00
PHST- 1992/02/01 00:00 [pubmed]
PHST- 1992/02/01 00:01 [medline]
PHST- 1992/02/01 00:00 [entrez]
PHST- 1992/02/01 00:00 [pmc-release]
AID - CAE146 [pii]
AID - 10.1111/j.1349-7006.1992.tb00079.x [doi]
PST - ppublish
SO  - Jpn J Cancer Res. 1992 Feb;83(2):146-52. doi: 10.1111/j.1349-7006.1992.tb00079.x.