PMID- 15561255
OWN - NLM
STAT- MEDLINE
DCOM- 20050505
LR  - 20041124
IS  - 0041-1345 (Print)
IS  - 0041-1345 (Linking)
VI  - 36
IP  - 8
DP  - 2004 Oct
TI  - Heart transplant coronary artery disease in Chinese recipients.
PG  - 2380-3
AB  - BACKGROUND: Transplant coronary artery disease is the principle limiting factor 
      for long-term survival of heart transplantation (HTx) recipients. We reviewed our 
      data to assess the incidence of this disorder among Chinese HTx recipients and to 
      compare it with the results of Western studies. MATERIAL AND METHODS: From July 
      1988 to May 2002, 182 patients received 184 orthotopic HTx. One hundred 
      sixty-three recipients survived for at least 1 year with available SPECT scans or 
      coronary angiogram studies. The data set included donor characteristics, 
      recipient characteristics, active cytomegalovirus (CMV) infection rate, rejection 
      episodes, immunosuppressants, and human leukocyte antigen (HLA) mismatches. 
      RESULTS: Surgical mortality in our program was 4.3% and the actuarial freedom 
      from coronary artery disease at 1, 3, and 5 years was 99%, 95%, and 92%, 
      respectively. Angiogram results were stratified into coronary artery disease (n = 
      15) or absence of the disorder (n = 148) groups. Only older donor age showed 
      statistical significance between the groups. Compared with the Western series, 
      the present data show higher actuarial survival rates and freedom from coronary 
      artery disease. There were statistically significant differences in regard to 
      graft ischemia time, proportion of male recipients, ischemic heart disease, 
      rejection episodes during the first year, and incidence of CMV infection. 
      CONCLUSIONS: SPECT scan can detect coronary artery disease before there is 
      significant stenosis of the coronary artery with acceptable survival rates. 
      Chinese HTx recipients show a lower incidence of the disorder, lower rates of 
      ischemia heart disease, lower proportion of male gender, lower incidence of CMV 
      infection, fewer rejection episodes during the first year, and less ischemic time 
      than Western recipients, which maybe the contributing factors to their better 
      survival.
FAU - Lee, K C
AU  - Lee KC
AD  - Heart Center, Cheng Hsin General Hospital, Taipei, Taiwan. ch9066@chgh.org.tw
FAU - Chang, C Y
AU  - Chang CY
FAU - Chuang, Y C
AU  - Chuang YC
FAU - Young, M S
AU  - Young MS
FAU - Huang, C M
AU  - Huang CM
FAU - Yin, W H
AU  - Yin WH
FAU - Tung, D Y
AU  - Tung DY
FAU - Lee, W C
AU  - Lee WC
FAU - Lee, S L
AU  - Lee SL
FAU - Sue, S H
AU  - Sue SH
FAU - Wei, J
AU  - Wei J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - Adult
MH  - China/ethnology
MH  - Coronary Disease/*complications/mortality
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Transplantation/methods/mortality/*physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Survival Analysis
MH  - Taiwan
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2004/11/25 09:00
MHDA- 2005/05/06 09:00
CRDT- 2004/11/25 09:00
PHST- 2004/11/25 09:00 [pubmed]
PHST- 2005/05/06 09:00 [medline]
PHST- 2004/11/25 09:00 [entrez]
AID - S0041-1345(04)00725-0 [pii]
AID - 10.1016/j.transproceed.2004.06.044 [doi]
PST - ppublish
SO  - Transplant Proc. 2004 Oct;36(8):2380-3. doi: 10.1016/j.transproceed.2004.06.044.