PMID- 15563541
OWN - NLM
STAT- MEDLINE
DCOM- 20050420
LR  - 20200930
IS  - 0363-6135 (Print)
IS  - 0363-6135 (Linking)
VI  - 288
IP  - 4
DP  - 2005 Apr
TI  - Assessment of left ventricular diastolic suction in dogs using wave-intensity 
      analysis.
PG  - H1641-51
AB  - Two apparently different types of mechanisms have emerged to explain diastolic 
      suction (DS), that property of the left ventricle (LV) that tends to cause it to 
      refill itself during early diastole independent of any force from the left atrium 
      (LA). By means of the first mechanism, DS depends on decreased elastance [e.g., 
      the relaxation time constant (tau)] and, by the second, end-systolic volume 
      (V(LVES)). We used wave-intensity analysis (WIA) to measure the total energy 
      transported by the backward expansion wave (I(W-)) during LV relaxation in an 
      attempt to reconcile these mechanisms. In six anesthetized, open-chest dogs, we 
      measured aortic, LV (P(LV)), LA (P(LA)), and pericardial pressures and LV volume 
      by orthogonal ultrasonic crystals. Mitral velocity was measured by Doppler 
      echocardiography, and aortic velocity was measured by an ultrasonic flow probe. 
      Heart rate was controlled by pacing, V(LVES) by volume loading, and tau by 
      isoproterenol or esmolol administration. I(W-) was found to be inversely related 
      to tau and V(LVES). Our measure of DS, the energy remaining after mitral valve 
      opening, I(W-DS), was also found to be inversely related to tau and V(LVES) and 
      was approximately 10% of the total "aspirating" energy generated by LV relaxation 
      (i.e., I(W-)). The size of the Doppler (early filling) E wave depended on I(W-DS) 
      in addition to I(W+), the energy associated with LA decompression. We conclude 
      that the energy of the backward-going wave generated by the LV during relaxation 
      depends on both the rate at which elastance decreases (i.e., tau) and V(LVES). 
      WIA provides a new approach for assessing DS and reconciles those two previously 
      proposed mechanisms. The E wave depends on DS in addition to LA decompression.
FAU - Wang, Zhibin
AU  - Wang Z
AD  - Qingdao University Medical College Hospital, Qingdao, China.
FAU - Jalali, Fereshteh
AU  - Jalali F
FAU - Sun, Yi-Hui
AU  - Sun YH
FAU - Wang, Jiun-Jr
AU  - Wang JJ
FAU - Parker, Kim H
AU  - Parker KH
FAU - Tyberg, John V
AU  - Tyberg JV
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20041124
PL  - United States
TA  - Am J Physiol Heart Circ Physiol
JT  - American journal of physiology. Heart and circulatory physiology
JID - 100901228
SB  - IM
EIN - Am J Physiol Heart Circ Physiol. 2005 Jun;288(6):H3017
MH  - Animals
MH  - Blood Pressure/physiology
MH  - Diastole/*physiology
MH  - Dogs
MH  - Echocardiography, Doppler
MH  - Elasticity
MH  - Mitral Valve/physiology
MH  - *Models, Cardiovascular
MH  - Stroke Volume/physiology
MH  - Suction
MH  - Ventricular Function, Left/*physiology
EDAT- 2004/11/26 09:00
MHDA- 2005/04/21 09:00
CRDT- 2004/11/26 09:00
PHST- 2004/11/26 09:00 [pubmed]
PHST- 2005/04/21 09:00 [medline]
PHST- 2004/11/26 09:00 [entrez]
AID - 00181.2004 [pii]
AID - 10.1152/ajpheart.00181.2004 [doi]
PST - ppublish
SO  - Am J Physiol Heart Circ Physiol. 2005 Apr;288(4):H1641-51. doi: 
      10.1152/ajpheart.00181.2004. Epub 2004 Nov 24.