PMID- 15564346
OWN - NLM
STAT- MEDLINE
DCOM- 20050831
LR  - 20220330
IS  - 1534-7796 (Electronic)
IS  - 0033-3174 (Linking)
VI  - 66
IP  - 6
DP  - 2004 Nov-Dec
TI  - Anxiety and depression in patients with pulmonary hypertension.
PG  - 831-6
AB  - OBJECTIVE: This is the first study that investigates the prevalence and actual 
      treatment of anxiety, depression, and other mental disorders in patients with 
      pulmonary hypertension (PH). The prevalence of mental disorders in patients with 
      PH was compared with parallel groups of primary care patients and patients with 
      inflammatory rheumatic diseases, and the relationship between functional status 
      and prevalence of mental disorders was determined. METHODS: The patient group 
      with PH (70.1% female; mean age, 47.8 +/- 12.7 years) and the two comparison 
      groups, which were matched by age and sex, consisted of 164 patients each. 
      Patients completed self-administered instruments, including the Patient Health 
      Questionnaire for the diagnosis of mental disorders. New York Heart Association 
      (NYHA) functional class was assessed in all patients with PH. RESULTS: 
      Thirty-five percent of the patients with PH suffered from mental disorders, with 
      the most common being major depressive disorder (15.9%) and panic disorder 
      (10.4%). Both panic disorder and panic attacks were significantly more prevalent 
      in patients with PH than in either patients with inflammatory rheumatic diseases 
      or primary care patients. The prevalence of mental disorders in patients with PH 
      increased significantly with functional impairment, from 17.7% (NYHA class I) to 
      61.9% (NYHA class IV). Only 24.1% of the patients with PH with mental disorders 
      were receiving psychopharmacological or psychotherapeutic treatment. CONCLUSIONS: 
      Anxiety and depression are frequent in patients with PH and increase as the 
      severity of disease progresses. Given the fact that safe and efficacious 
      treatments of mental disorders are available, greater importance should be 
      attached to the diagnosis and treatment of these conditions in patients with PH.
FAU - Lowe, Bernd
AU  - Lowe B
AD  - Department of General Internal and Psychosomatic Medicine, University of 
      Heidelberg, Medical Center, Im Neuenheimer Feld 410, D-69120 Heidelberg, Germany. 
      bernd.loewe@med.uni-heidelberg.de
FAU - Grafe, Kerstin
AU  - Grafe K
FAU - Ufer, Christiane
AU  - Ufer C
FAU - Kroenke, Kurt
AU  - Kroenke K
FAU - Grunig, Ekkehard
AU  - Grunig E
FAU - Herzog, Wolfgang
AU  - Herzog W
FAU - Borst, Mathias M
AU  - Borst MM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Psychosom Med
JT  - Psychosomatic medicine
JID - 0376505
RN  - 0 (Psychotropic Drugs)
SB  - IM
MH  - Anxiety Disorders/diagnosis/*epidemiology/therapy
MH  - Austria/epidemiology
MH  - Comorbidity
MH  - Depressive Disorder/diagnosis/*epidemiology/therapy
MH  - Female
MH  - Germany/epidemiology
MH  - Health Services Accessibility
MH  - Health Status
MH  - Humans
MH  - Hypertension, Pulmonary/diagnosis/*epidemiology/psychology
MH  - Male
MH  - Mental Disorders/diagnosis/epidemiology
MH  - Middle Aged
MH  - Panic Disorder/diagnosis/epidemiology/therapy
MH  - Prevalence
MH  - Psychotherapy
MH  - Psychotropic Drugs/therapeutic use
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
MH  - Switzerland/epidemiology
EDAT- 2004/11/27 09:00
MHDA- 2005/09/01 09:00
CRDT- 2004/11/27 09:00
PHST- 2004/11/27 09:00 [pubmed]
PHST- 2005/09/01 09:00 [medline]
PHST- 2004/11/27 09:00 [entrez]
AID - 66/6/831 [pii]
AID - 10.1097/01.psy.0000145593.37594.39 [doi]
PST - ppublish
SO  - Psychosom Med. 2004 Nov-Dec;66(6):831-6. doi: 10.1097/01.psy.0000145593.37594.39.