PMID- 15564818
OWN - NLM
STAT- MEDLINE
DCOM- 20050201
LR  - 20071114
IS  - 0890-8567 (Print)
IS  - 0890-8567 (Linking)
VI  - 43
IP  - 12
DP  - 2004 Dec
TI  - Comparison of increasingly detailed elicitation methods for the assessment of 
      adverse events in pediatric psychopharmacology.
PG  - 1488-96
AB  - OBJECTIVE: To improve the gathering of adverse events (AEs) in pediatric 
      psychopharmacology by examining the value and acceptability of increasingly 
      detailed elicitation methods. METHOD: Trained clinicians administered the Safety 
      Monitoring Uniform Report Form (SMURF) to 59 parents and outpatients (mean age 
      +/- SD = 11.9 +/- 3.2 years) in treatment, with 36% on stimulants, 29% on 
      selective serotonin reuptake inhibitor drugs, 10% on both, and 25% on other drug 
      combinations. The SMURF included a brief general inquiry, a drug-specific 
      inquiry, and a comprehensive body system review (BSR). RESULTS: SMURF 
      administration took 24.6 +/- 13.9 minutes (median, 21). The BSR took 15.5 +/- 8.1 
      minutes (median, 14) longer (p < .0001) than the general inquiry (4.3 +/- 5.4 
      minutes) and the drug-specific inquiry (4.2 +/- 2.9 minutes). The general inquiry 
      elicited 48 AEs, the drug-specific inquiry elicited 16 additional AEs, and the 
      BSR 129 additional AEs. Of all the clinically relevant AEs elicited by the SMURF 
      (n = 36), 19 (53%) were elicited by the BSR. The BSR length and detail were 
      acceptable to parents but not to clinicians. CONCLUSIONS: The BSR elicited 
      additional clinically significant AEs that had been missed with less detailed 
      methods. Parents, but not clinicians, rated satisfaction and acceptability of the 
      BSR as good.
FAU - Greenhill, Laurence L
AU  - Greenhill LL
AD  - New York State Psychiatric Institute, Columbia University, USA. 
      greenhil@child.cpmc.columbia.edu
FAU - Vitiello, Benedetto
AU  - Vitiello B
FAU - Fisher, Prudence
AU  - Fisher P
FAU - Levine, Jerome
AU  - Levine J
FAU - Davies, Mark
AU  - Davies M
FAU - Abikoff, Howard
AU  - Abikoff H
FAU - Chrisman, Allan K
AU  - Chrisman AK
FAU - Chuang, Shirley
AU  - Chuang S
FAU - Findling, Robert L
AU  - Findling RL
FAU - March, John
AU  - March J
FAU - Scahill, Lawrence
AU  - Scahill L
FAU - Walkup, John
AU  - Walkup J
FAU - Riddle, Mark A
AU  - Riddle MA
LA  - eng
GR  - N01MH60005/MH/NIMH NIH HHS/United States
GR  - N01MH60016/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Am Acad Child Adolesc Psychiatry
JT  - Journal of the American Academy of Child and Adolescent Psychiatry
JID - 8704565
RN  - 0 (Psychotropic Drugs)
SB  - IM
MH  - Adolescent
MH  - *Adverse Drug Reaction Reporting Systems
MH  - Child
MH  - Feasibility Studies
MH  - Female
MH  - *Health Status
MH  - Humans
MH  - Male
MH  - Mental Disorders/*drug therapy
MH  - Psychopharmacology/*methods
MH  - Psychotropic Drugs/*adverse effects
MH  - Quality Assurance, Health Care/*methods
EDAT- 2004/11/27 09:00
MHDA- 2005/02/03 09:00
CRDT- 2004/11/27 09:00
PHST- 2004/11/27 09:00 [pubmed]
PHST- 2005/02/03 09:00 [medline]
PHST- 2004/11/27 09:00 [entrez]
AID - S0890-8567(09)61382-4 [pii]
AID - 10.1097/01.chi.0000142668.29191.13 [doi]
PST - ppublish
SO  - J Am Acad Child Adolesc Psychiatry. 2004 Dec;43(12):1488-96. doi: 
      10.1097/01.chi.0000142668.29191.13.