PMID- 15566505
OWN - NLM
STAT- MEDLINE
DCOM- 20050322
LR  - 20151119
IS  - 1478-3223 (Print)
IS  - 1478-3223 (Linking)
VI  - 24
IP  - 6
DP  - 2004 Dec
TI  - Vigorous response of cytotoxic T lymphocytes associated with systemic activation 
      of CD8 T lymphocytes in fulminant hepatitis B.
PG  - 561-7
AB  - BACKGROUND: Fulminant hepatitis is a clinical syndrome characterized by sudden 
      and severe liver dysfunction. METHODS: We analyzed two patients with a superacute 
      form of fulminant hepatitis B and compared findings with those of four patients 
      with acute self-limited hepatitis B, two patients with acute exacerbation of 
      chronic hepatitis B and four healthy individuals. RESULTS: In fulminant 
      hepatitis, an increased population of human leukocyte antigen (HLA)-DR(+) CD8(+) 
      lymphocytes was observed in peripheral blood by flow cytometry, which was 
      accompanied by the presence of HLA-DR(hi) lymphocytes. The phenotype of CD8(+) T 
      lymphocytes from patients with fulminant hepatitis was mostly that of the 
      effector T lymphocytes in peripheral blood, whereas lymphocytes with CD45RA(-) 
      CCR7(-) phenotype dominated in the liver of these patients. A larger population 
      of hepatitis B virus (HBV)-specific cytotoxic T lymphocytes (CTLs) appeared in 
      peripheral circulation of the fulminant hepatitis patients compared with that in 
      a patient with acute hepatitis. HBV-specific CTLs were highly concentrated in the 
      liver, although epitopes recognized by these CTLs in the peripheral blood and in 
      the liver were similar. Peripheral CTLs were mostly functional as indicated by 
      intracellular perforin and interferon-gamma. CONCLUSIONS: These results suggest 
      the presence of vigorous activation of CD8(+) T cells in vivo in fulminant 
      hepatitis and the necessity of extensive therapy in patients with this disease.
FAU - Kondo, Y
AU  - Kondo Y
AD  - Tohoku University Graduate School of Medicine, Sendai, Japan.
FAU - Kobayashi, K
AU  - Kobayashi K
FAU - Asabe, S
AU  - Asabe S
FAU - Shiina, M
AU  - Shiina M
FAU - Niitsuma, H
AU  - Niitsuma H
FAU - Ueno, Y
AU  - Ueno Y
FAU - Kobayashi, T
AU  - Kobayashi T
FAU - Shimosegawa, T
AU  - Shimosegawa T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Liver Int
JT  - Liver international : official journal of the International Association for the 
      Study of the Liver
JID - 101160857
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Biomarkers/analysis
MH  - CD8-Positive T-Lymphocytes/*immunology
MH  - Case-Control Studies
MH  - Disease Progression
MH  - Female
MH  - Hepatectomy/methods
MH  - Hepatic Encephalopathy/*immunology/pathology
MH  - Hepatitis B/*immunology/pathology/surgery
MH  - Humans
MH  - Immunohistochemistry
MH  - Lymphocyte Activation
MH  - Male
MH  - Middle Aged
MH  - Sampling Studies
MH  - Sensitivity and Specificity
MH  - T-Lymphocytes, Cytotoxic/*immunology
EDAT- 2004/11/30 09:00
MHDA- 2005/03/23 09:00
CRDT- 2004/11/30 09:00
PHST- 2004/11/30 09:00 [pubmed]
PHST- 2005/03/23 09:00 [medline]
PHST- 2004/11/30 09:00 [entrez]
AID - LIV982 [pii]
AID - 10.1111/j.1478-3231.2004.0982.x [doi]
PST - ppublish
SO  - Liver Int. 2004 Dec;24(6):561-7. doi: 10.1111/j.1478-3231.2004.0982.x.