PMID- 15566665
OWN - NLM
STAT- MEDLINE
DCOM- 20050805
LR  - 20181201
VI  - 23
IP  - 11 Suppl
DP  - 2004 Nov
TI  - [Survivin expression in laryngeal squamous cell carcinoma and its relationship 
      with clinical factors].
PG  - 1493-7
AB  - BACKGROUND & OBJECTIVE: Survivin, a new described member of the family of 
      apoptosis inhibitory proteins (IAP), is undetectable in normal tissue of adults, 
      but abundantly expressed in a variety of human malignancies. This study was 
      designed to examine the expression of Survivin in laryngeal squamous cell 
      carcinoma, analyze the relationships between the expression of Survivin and 
      prognostic factors including age, gender, clinical stage, T stage, N stage, 
      classification, histology and recurrence, to investigate its significance on 
      prognosis. METHODS: Clinical information and paraffin- embedded tumor samples of 
      81 cases laryngeal squamous cell carcinoma (LSCC) patients, who were treated at 
      Cancer Center of Sun Yat-sen University between 1997 and 1998, were collected. 
      Tissue chip was made, and SP method was performed to analyze Survivin expression 
      in tumor tissue and adjacent normal laryngeal mucosa. SPSS 10.0 software was 
      used. Kaplan-Meier method was used for survival analysis, and log-rank test was 
      used for data analysis; multivariate analysis was carried out using Cox 
      proportional hazard model. RESULTS: The overall 5-year survival rate for patients 
      with laryngeal squamous cell carcinoma in this study was 58.33%. The 
      over-expression rate of Survivin in tumor tissue and adjacent normal laryngeal 
      tissue were 50.62%, 0%, respectively (P< 0.05). The positive Survivin expression 
      group(5-year overall surivial rate: 22.06%) had a worse prognosis than that of 
      negative group (5- year overall survival rate: 92.33%)(P< 0.05). The univariate 
      analysis showed that clinical stage, T stage, N stage, histology grade, 
      recurrence, and Survivin expression were the most important prognostic factors 
      (P< 0.05). The Chi(2) test results showed that the expression of survivin was 
      correlated with clinical stage, T stage, N stage, histology grade and recurrence 
      (P< 0.05); Multivariate analysis results showed that clinical stage, survivin 
      expression, and recurrence were independent prognosis factors on survival in LSCC 
      patients. CONCLUSIONS: The expression of Survivin is an important biological 
      factor affecting the prognosis; Tissue chip method can be simply and efficiently 
      used in large scale of retrospective study in laryngeal squamous cell carcinoma.
FAU - Chen, Yan-Feng
AU  - Chen YF
AD  - Department of Head and Neck Surgery, Cancer Center, Sun Yat-sen University, 
      Guangzhou, Guangdong, 510060, P.R.China.
FAU - Chen, Fu-Jin
AU  - Chen FJ
FAU - Fang, Yan
AU  - Fang Y
FAU - Yang, An-Kui
AU  - Yang AK
FAU - Zhang, Quan
AU  - Zhang Q
FAU - Wu, Guo-Hao
AU  - Wu GH
LA  - chi
PT  - Journal Article
PL  - China
TA  - Ai Zheng
JT  - Ai zheng = Aizheng = Chinese journal of cancer
JID - 9424852
RN  - 0 (BIRC5 protein, human)
RN  - 0 (Inhibitor of Apoptosis Proteins)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Survivin)
SB  - IM
MH  - Carcinoma, Squamous Cell/*metabolism/secondary/surgery
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Inhibitor of Apoptosis Proteins
MH  - Laryngeal Neoplasms/*metabolism/pathology/surgery
MH  - Lymphatic Metastasis
MH  - Male
MH  - Microtubule-Associated Proteins/*metabolism
MH  - Neoplasm Proteins
MH  - Neoplasm Recurrence, Local
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Survival Rate
MH  - Survivin
MH  - Tissue Array Analysis
EDAT- 2004/11/30 09:00
MHDA- 2005/08/06 09:00
CRDT- 2004/11/30 09:00
PHST- 2004/11/30 09:00 [pubmed]
PHST- 2005/08/06 09:00 [medline]
PHST- 2004/11/30 09:00 [entrez]
AID - 1000467X200411s1493 [pii]
PST - ppublish
SO  - Ai Zheng. 2004 Nov;23(11 Suppl):1493-7.