PMID- 15567501
OWN - NLM
STAT- MEDLINE
DCOM- 20050429
LR  - 20181201
IS  - 0168-3659 (Print)
IS  - 0168-3659 (Linking)
VI  - 100
IP  - 3
DP  - 2004 Dec 10
TI  - In vitro degradation of nanoparticles prepared from polymers based on DL-lactide, 
      glycolide and poly(ethylene oxide).
PG  - 347-56
AB  - Nanoparticles of poly(DL-lactic acid) (PDLLA), poly(DL-lactic-co-glycolic acid) 
      (PLGA) and poly(ethylene oxide)-PLGA diblock copolymer (PEO-PLGA) were prepared 
      by the salting-out method. The in vitro degradation of PDLLA, PLGA and PEO-PLGA 
      nanoparticles in PBS (pH 7.4) at 37 degrees C was studied. The particle size, 
      molecular weight of the polymers and the amount of lactic and glycolic acids 
      formed were followed in time. PDLLA nanoparticles gradually degraded over a 
      period of 2 years and retain their size during that period. A faster degradation 
      was observed for PLGA nanoparticles, which was nearly complete after 10 weeks. 
      PLGA nanoparticles retained their size during that period. In PEO-PLGA 
      nanoparticles, the ester bond connecting the PEO and the PLGA segments was 
      preferentially cleaved, which led to a relatively fast decrease in molecular 
      weight and to (partial) aggregation, as multimodal size distributions were 
      observed. PEO-PLGA nanoparticles were almost completely degraded within 8 weeks.
FAU - Zweers, Miechel L T
AU  - Zweers ML
AD  - Department of Polymer Chemistry and Biomaterials, Institute for Biomedical 
      Technology, Faculty of Science and Technology, Twente University, P.O. Box 217, 
      7500 AE Enschede, The Netherlands.
FAU - Engbers, Gerard H M
AU  - Engbers GH
FAU - Grijpma, Dirk W
AU  - Grijpma DW
FAU - Feijen, Jan
AU  - Feijen J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Control Release
JT  - Journal of controlled release : official journal of the Controlled Release 
      Society
JID - 8607908
RN  - 0 (Excipients)
RN  - 0 (Polyesters)
RN  - 0 (Polymers)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 459TN2L5F5 (poly(lactide))
SB  - IM
MH  - Algorithms
MH  - Drug Compounding
MH  - Drug Stability
MH  - Excipients/*chemistry
MH  - Lactic Acid/chemistry
MH  - Microspheres
MH  - Molecular Weight
MH  - Particle Size
MH  - Polyesters/*chemistry
MH  - Polyethylene Glycols/*chemistry
MH  - Polyglycolic Acid/*chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Polymers/chemistry
EDAT- 2004/11/30 09:00
MHDA- 2005/04/30 09:00
CRDT- 2004/11/30 09:00
PHST- 2004/01/30 00:00 [received]
PHST- 2004/09/16 00:00 [accepted]
PHST- 2004/11/30 09:00 [pubmed]
PHST- 2005/04/30 09:00 [medline]
PHST- 2004/11/30 09:00 [entrez]
AID - S0168-3659(04)00442-0 [pii]
AID - 10.1016/j.jconrel.2004.09.008 [doi]
PST - ppublish
SO  - J Control Release. 2004 Dec 10;100(3):347-56. doi: 10.1016/j.jconrel.2004.09.008.