PMID- 15567915
OWN - NLM
STAT- MEDLINE
DCOM- 20041217
LR  - 20190710
IS  - 0302-5144 (Print)
IS  - 0302-5144 (Linking)
VI  - 146
DP  - 2005
TI  - Renal transplantation. Strategies to prevent organ rejection--the role of an 
      inter-regional reference center.
PG  - 1-10
LID - 10.1159/000082056 [doi]
AB  - This paper summarizes the role of the Inter-Regional Reference Center (RC) of the 
      North Italy Transplant program (NITp), in coordinating a donor procurement and 
      organ transplantation network, with a special focus on the strategies to minimize 
      immunological risk and complications after transplantation. In the NITp, patients 
      enrolled on the renal transplantation (RT) waiting list are typed for 
      HLA-A,B,DRB1 antigens with a genomic method. They are periodically screened for 
      the presence of lymphocytotoxic antibodies in their serum by the RC and their 
      suitability to receive the transplant is checked periodically. Cadaver kidney 
      allocation is ruled by a computerized algorithm, named NITK3, established in 
      1997, which aims at ensuring quality, equity, transparency and traceability 
      during all the phases of the allocation decision-making process. NITK3 has been 
      set up by the NITp Working Group on the basis of biological, medical and 
      administrative criteria and it is periodically reviewed after the analysis of 
      transplant results. In this paper, we show the results of a preliminary analysis 
      of RTs performed from 1998 to 2002 in nine out of sixteen centers of the NITp 
      area, which demonstrates the general quality of the NITp program in terms of 
      patients and graft survival and the special attention to the patients at higher 
      immunological risk.
FAU - Cardillo, Massimo
AU  - Cardillo M
AD  - Dipartimento Trasfusionale e di Riferimento per il Trapianto di Organi e Tessuti, 
      RCCS Ospedale Maggiore Policlinico, Milano; Italy.
FAU - Poli, Francesca
AU  - Poli F
FAU - Barraco, Fiorenza
AU  - Barraco F
FAU - Fazio, Nicola De
AU  - Fazio N
FAU - Rossini, Giuseppe
AU  - Rossini G
FAU - Boschiero, Luigi
AU  - Boschiero L
FAU - Nocera, Arcangelo
AU  - Nocera A
FAU - Rigotti, Paolo
AU  - Rigotti P
FAU - Marchini, Francesco
AU  - Marchini F
FAU - Zacchello, Graziella
AU  - Zacchello G
FAU - Zanon, Gianfranco
AU  - Zanon G
FAU - Sandrini, Silvio
AU  - Sandrini S
FAU - Chiaramonte, Stefano
AU  - Chiaramonte S
FAU - Maresca, Cristina
AU  - Maresca C
FAU - Caldara, Rossana
AU  - Caldara R
FAU - Messa, Piergiorgio
AU  - Messa P
FAU - Berardinelli, Luisa
AU  - Berardinelli L
FAU - Ambrosini, Andrea
AU  - Ambrosini A
FAU - Montanaro, Domenico
AU  - Montanaro D
FAU - Rampino, Teresa
AU  - Rampino T
FAU - Minetti, Enrico
AU  - Minetti E
FAU - Gotti, Eliana
AU  - Gotti E
FAU - Ghio, Luciana
AU  - Ghio L
FAU - Ginevri, Fabrizio
AU  - Ginevri F
FAU - Albertario, Fulvio
AU  - Albertario F
FAU - Scalamogna, Mario
AU  - Scalamogna M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Switzerland
TA  - Contrib Nephrol
JT  - Contributions to nephrology
JID - 7513582
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Graft Rejection/*prevention & control
MH  - Humans
MH  - Italy
MH  - Kidney Transplantation/*adverse effects/methods
MH  - Male
MH  - Middle Aged
MH  - Program Development
MH  - Program Evaluation
MH  - Registries
MH  - Tissue Donors
MH  - Tissue and Organ Procurement/*organization & administration
MH  - Waiting Lists
RF  - 12
EDAT- 2004/11/30 09:00
MHDA- 2004/12/18 09:00
CRDT- 2004/11/30 09:00
PHST- 2004/11/30 09:00 [pubmed]
PHST- 2004/12/18 09:00 [medline]
PHST- 2004/11/30 09:00 [entrez]
AID - 000082056 [pii]
AID - 10.1159/000082056 [doi]
PST - ppublish
SO  - Contrib Nephrol. 2005;146:1-10. doi: 10.1159/000082056.