PMID- 15569870
OWN - NLM
STAT- MEDLINE
DCOM- 20050901
LR  - 20161122
IS  - 1524-4628 (Electronic)
IS  - 0039-2499 (Linking)
VI  - 36
IP  - 1
DP  - 2005 Jan
TI  - Impaired functional recovery after stroke in the stroke-prone spontaneously 
      hypertensive rat.
PG  - 135-41
AB  - BACKGROUND AND PURPOSE: To identify if the stroke-prone spontaneously 
      hypertensive rat (SHRSP) exhibits impaired functional recovery after stroke 
      compared with its normotensive reference strain, the Wistar Kyoto rat (WKY). 
      METHODS: In study 1, a 2-mm distal middle cerebral artery occlusion (middle 
      cerebral artery occlusion) was performed in both strains and recovery assessed 
      using a 33-point neurological score. Because SHRSPs displayed much larger 
      infarcts than WKYs, study 2 and study 3 involved extending the length of middle 
      cerebral artery (MCA) occlusion in the WKY to increase the volume and 
      distribution of infarction to comparable levels with SHRSP. Animals were assessed 
      with the neurological score, tapered beam walk, and cylinder tests. RESULTS: In 
      study 1, infarct volume (expressed as a percent of contralateral hemisphere) was 
      WKY 13.1+/-3% and SHRSP 19.8+/-1%. Initial neurological deficit was greater (WKY 
      25+/-1, SHRSP 22+/-1, out of a possible 33) and subsequent recovery was poorer in 
      SHRSP. In studies 2 and 3, infarct volume and distribution (study 2, WKY 
      21.8+/-1.3%, SHRSP 22.9+/-3%; study 3, WKY 17.2+/-2%, SHRSP 16.5+/-3%) and 
      initial neurological deficit at 2 hours after middle cerebral artery occlusion 
      (study 2 WKY 23+/-1, SHRSP 22+/-2; study 3 WKY 25+/-1 and SHRSP 23+/-1; 
      mean+/-SEM) were comparable between strains. However, whereas WKY recovered 
      toward normal scores, SHRSP scored significantly lower 2 weeks (study 2) and 4 
      weeks (study 3) after middle cerebral artery occlusion. Beam walk data revealed 
      long-term impairment in SHRSP contralateral limb use, compared with WKY, at days 
      3, 7, and 28 (P<0.05). CONCLUSIONS: SHRSP exhibit impaired functional recovery 
      after stroke compared with WKY.
FAU - McGill, J K
AU  - McGill JK
AD  - Division of Clinical Neuroscience, Wellcome Surgical Institute, University of 
      Glasgow, Switchback Road, Glasgow, G61 1QH. 9606685m@student.gla.ac.uk
FAU - Gallagher, L
AU  - Gallagher L
FAU - Carswell, H V O
AU  - Carswell HV
FAU - Irving, E A
AU  - Irving EA
FAU - Dominiczak, A F
AU  - Dominiczak AF
FAU - Macrae, I M
AU  - Macrae IM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20041129
PL  - United States
TA  - Stroke
JT  - Stroke
JID - 0235266
SB  - IM
MH  - Animals
MH  - Behavior, Animal
MH  - Hypertension/*complications
MH  - Infarction, Middle Cerebral Artery/complications/pathology
MH  - Male
MH  - Motor Activity
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Stroke/etiology/*physiopathology
EDAT- 2004/12/01 09:00
MHDA- 2005/09/02 09:00
CRDT- 2004/12/01 09:00
PHST- 2004/12/01 09:00 [pubmed]
PHST- 2005/09/02 09:00 [medline]
PHST- 2004/12/01 09:00 [entrez]
AID - 01.STR.0000149629.32525.b7 [pii]
AID - 10.1161/01.STR.0000149629.32525.b7 [doi]
PST - ppublish
SO  - Stroke. 2005 Jan;36(1):135-41. doi: 10.1161/01.STR.0000149629.32525.b7. Epub 2004 
      Nov 29.