PMID- 15570414
OWN - NLM
STAT- MEDLINE
DCOM- 20050509
LR  - 20181113
IS  - 0937-941X (Print)
IS  - 0937-941X (Linking)
VI  - 15
IP  - 12
DP  - 2004 Dec
TI  - Reference database of biochemical markers of bone turnover for the Japanese 
      female population. Japanese Population-based Osteoporosis (JPOS) Study.
PG  - 981-91
AB  - The present study was conducted as a part of the Japanese Population-based 
      Osteoporosis (JPOS) Study to establish reference values on the biochemical 
      markers of bone turnover in the general Japanese female population over an 
      applicable age range. The study recruited 3250 women aged 15-79 years, randomly 
      selected from five municipalities throughout Japan, and obtained measurements of 
      serum osteocalcin (OC) and bone-specific alkaline phosphatase (BAP); free and 
      total forms of immunoreactive deoxypyridinoline, free pyridinolines and type I 
      collagen cross-linked C-terminal telopeptide (CTx) in urine; serum intact 
      parathyroid hormone (PTH) and 1,25 dihydroxy vitamin D (1,25 (OH)2D); and bone 
      density at the spine, hip and distal forearm. After excluding subjects with 
      apparent or suggested abnormalities affecting bone mass, 2535 (78%) subjects were 
      further analyzed. The authors presented 5-year age-specific mean values of the 
      markers and mean marker levels derived from women aged 30-44 years with normal 
      bone density as a healthy young adult reference. Values of the markers decreased 
      with increasing age before the age of 40, increased steeply among subjects in 
      their 50s, and remained elevated in the elderly. Serum calcium, phosphorus, PTH 
      and 1,25 (OH)2D levels were higher in postmenopausal women than in premenopausal 
      women. However, 1,25 (OH)2D was lower among early postmenopausal subjects. The 
      levels of OC, BAP, CTx, PTH and 1,25(OH)2D were significantly greater for women 
      with osteoporosis than for those without. The diagnostic value of the markers was 
      limited as the sensitivity and specificity ranged from 55% to 60%. These findings 
      will aid health professionals in the correct assessment of bone turnover status 
      in Japanese women over a wide range of age.
FAU - Iki, Masayuki
AU  - Iki M
AD  - Department of Public Health, Kinki University School of Medicine , 377-2 
      Oono-Higashi, Osaka-Sayama, 589-8511 Osaka, Japan. masa@med.kindai.ac.jp
FAU - Akiba, Takashi
AU  - Akiba T
FAU - Matsumoto, Toshio
AU  - Matsumoto T
FAU - Nishino, Harumi
AU  - Nishino H
FAU - Kagamimori, Sadanobu
AU  - Kagamimori S
FAU - Kagawa, Yoshiko
AU  - Kagawa Y
FAU - Yoneshima, Hideo
AU  - Yoneshima H
CN  - JPOS Study Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20040731
PL  - England
TA  - Osteoporos Int
JT  - Osteoporosis international : a journal established as result of cooperation 
      between the European Foundation for Osteoporosis and the National Osteoporosis 
      Foundation of the USA
JID - 9100105
RN  - 0 (Amino Acids)
RN  - 0 (Biomarkers)
RN  - 0 (Collagen Type I)
RN  - 0 (Parathyroid Hormone)
RN  - 0 (Peptides)
RN  - 0 (collagen type I trimeric cross-linked peptide)
RN  - 104982-03-8 (Osteocalcin)
RN  - 63800-01-1 (pyridinoline)
RN  - 90032-33-0 (deoxypyridinoline)
RN  - 9007-34-5 (Collagen)
RN  - EC 3.1.3.1 (Alkaline Phosphatase)
RN  - FXC9231JVH (Calcitriol)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alkaline Phosphatase/blood
MH  - Amino Acids/urine
MH  - Biomarkers/blood/urine
MH  - Bone Density
MH  - *Bone Remodeling
MH  - Calcitriol/blood
MH  - Collagen/urine
MH  - Collagen Type I
MH  - *Databases, Factual
MH  - Female
MH  - Humans
MH  - Japan
MH  - Middle Aged
MH  - Osteocalcin/blood
MH  - Osteoporosis/blood/urine
MH  - Parathyroid Hormone/blood
MH  - Peptides/urine
MH  - Reference Values
EDAT- 2004/12/01 09:00
MHDA- 2005/05/10 09:00
CRDT- 2004/12/01 09:00
PHST- 2003/10/10 00:00 [received]
PHST- 2004/03/11 00:00 [accepted]
PHST- 2004/12/01 09:00 [pubmed]
PHST- 2005/05/10 09:00 [medline]
PHST- 2004/12/01 09:00 [entrez]
AID - 10.1007/s00198-004-1634-1 [doi]
PST - ppublish
SO  - Osteoporos Int. 2004 Dec;15(12):981-91. doi: 10.1007/s00198-004-1634-1. Epub 2004 
      Jul 31.