PMID- 15570995
OWN - NLM
STAT- MEDLINE
DCOM- 20050215
LR  - 20220409
IS  - 0334-018X (Print)
IS  - 0334-018X (Linking)
VI  - 17
IP  - 11
DP  - 2004 Nov
TI  - Latent autoimmune diabetes mellitus in children (LADC) with autoimmune 
      thyroiditis and Celiac disease.
PG  - 1565-9
AB  - Latent autoimmune diabetes mellitus in adults (LADA) is characterized by clinical 
      presentation as type 2 diabetes mellitus after 25 years of age, initial control 
      achieved with oral hypoglycemic agents for at least 6 months, presence of 
      autoantibodies and some immunogenetic features of type 1 diabetes mellitus. An 
      8.3 year-old girl was referred to our pediatric endocrinology department because 
      of incidental glucosuria. She did not complain of polyuria, polydipsia, or weight 
      loss. Her body mass index (BMI) was at the 80th percentile. Fasting glucose was 
      126 mg/dl, and OGTT glucose level at 120 min was 307 mg/dl. Although C-peptide 
      levels were normal, her first phase insulin response (FIR) was lower than the 1st 
      percentile. Anti-insulin antibody (AIA), islet cell antibody (ICA), and 
      anti-glutamic acid decarboxylase (antiGAD) were negative. According to the 
      clinical and laboratory findings, she was diagnosed as having type 2 diabetes 
      mellitus. She was started with oral anti-diabetic treatment for a period of 1 
      year. Insulin had to be initiated for worsening of HbA1c levels. In the fourth 
      year of follow-up, she was admitted to our hospital with diabetic ketoacidosis 
      although she was on an intensive insulin regimen. At this time, C-peptide levels 
      were low, antiGAD and AIA were positive with HLA DR3/DQ2 haplotype. In addition, 
      her thyroid peroxidase antibody and endomysium antibody were found to be high at 
      follow-up. Small intestinal biopsy revealed celiac disease. This patient may 
      represent the first case of latent autoimmune diabetes mellitus in children 
      (LADC) with autoimmune thyroiditis and celiac disease.
FAU - Aycan, Zehra
AU  - Aycan Z
AD  - Department of Pediatric Endocrinology, Ankara University School of Medicine, 
      Ankara, Turkey. zehraaycan67@hotmail.com
FAU - Berberoglu, Merih
AU  - Berberoglu M
FAU - Adiyaman, Pelin
AU  - Adiyaman P
FAU - Ergur, Ayca Torel
AU  - Ergur AT
FAU - Ensari, Arzu
AU  - Ensari A
FAU - Evliyaoglu, Olcay
AU  - Evliyaoglu O
FAU - Siklar, Zeynep
AU  - Siklar Z
FAU - Ocal, Gonul
AU  - Ocal G
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Germany
TA  - J Pediatr Endocrinol Metab
JT  - Journal of pediatric endocrinology & metabolism : JPEM
JID - 9508900
RN  - 0 (Blood Glucose)
RN  - 0 (C-Peptide)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
SB  - IM
MH  - Blood Glucose/metabolism
MH  - Body Mass Index
MH  - C-Peptide/metabolism
MH  - Celiac Disease/*complications
MH  - Child
MH  - Diabetes Mellitus, Type 1/blood/*etiology
MH  - Female
MH  - Glycosuria/etiology
MH  - Humans
MH  - Hypoglycemic Agents/therapeutic use
MH  - Insulin/therapeutic use
MH  - Thyroiditis, Autoimmune/*complications
EDAT- 2004/12/02 09:00
MHDA- 2005/02/16 09:00
CRDT- 2004/12/02 09:00
PHST- 2004/12/02 09:00 [pubmed]
PHST- 2005/02/16 09:00 [medline]
PHST- 2004/12/02 09:00 [entrez]
AID - 10.1515/jpem.2004.17.11.1565 [doi]
PST - ppublish
SO  - J Pediatr Endocrinol Metab. 2004 Nov;17(11):1565-9. doi: 
      10.1515/jpem.2004.17.11.1565.