PMID- 15573260
OWN - NLM
STAT- MEDLINE
DCOM- 20050208
LR  - 20181113
IS  - 0364-2313 (Print)
IS  - 0364-2313 (Linking)
VI  - 28
IP  - 10
DP  - 2004 Oct
TI  - Improved health-related quality of life after coronary artery bypass grafting is 
      unrelated to use of cardiopulmonary bypass.
PG  - 1030-5
AB  - This prospective study was instituted to assess whether the use of the on-pump 
      method or the off-pump method affects changes in health-related quality of life 
      (QOL) as evaluated a year after coronary artery bypass graft (CABG) surgery. Data 
      including preoperative risk factors and postoperative morbidity up to discharge 
      were collected from 508 CABG patients operated in the Heart Center of a 
      university hospital and further treated in secondary referral hospitals. Four 
      hundred and fifty-two (89.0%) patients underwent operation with the on-pump 
      method and 56 (11.0%) with the off-pump method, i.e., without cardiopulmonary 
      bypass (CPB). The RAND-36 Health Survey (RAND-36) was used as indicator of QOL. 
      The primary outcome measure was a change in the physical component summary (PCS) 
      and mental component summary (MCS) from the RAND-36. Symptomatic status was 
      estimated according to New York Heart Association (NYHA) class. Assessments were 
      made preoperatively and repeated 12 months later. The majority of patients 
      operated on-pump (85.6%) and off-pump (92.9%) had a favorable outcome without 
      major complications (p = 0.136). The present data showed significant improvement 
      (p < 0.001) in all eight domains of QOL following on-pump CABG. Likewise, 
      off-pump patients improved in all eight aspects, and the change was statistically 
      significant in six dimensions. A highly significant (p < 0.001) pattern of change 
      was seen in the RAND-36 MCS and PCS scores in both operative groups. Differences 
      between the groups were nonsignificant. We conclude that most patients experience 
      significant improvement in health-related QOL during the first year after CABG, 
      and that cardiopulmonary bypass has no effect on patients' subsequent 
      health-related QOL, but its use depends on specific indications.
FAU - Jarvinen, Otso
AU  - Jarvinen O
AD  - Heart Center, Department of Cardiothoracic Surgery, Tampere University Hospital, 
      Box 2000 33521, Tampere, Finland. otsojarvinen@koti.soon.fi
FAU - Saarinen, Timo
AU  - Saarinen T
FAU - Julkunen, Juhani
AU  - Julkunen J
FAU - Laurikka, Jari
AU  - Laurikka J
FAU - Huhtala, Heini
AU  - Huhtala H
FAU - Tarkka, Matti R
AU  - Tarkka MR
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20040929
PL  - United States
TA  - World J Surg
JT  - World journal of surgery
JID - 7704052
SB  - IM
MH  - Aged
MH  - *Coronary Artery Bypass/methods
MH  - *Coronary Artery Bypass, Off-Pump
MH  - Female
MH  - Health Status Indicators
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Postoperative Period
MH  - Prospective Studies
MH  - *Quality of Life
EDAT- 2004/12/02 09:00
MHDA- 2005/02/09 09:00
CRDT- 2004/12/02 09:00
PHST- 2004/12/02 09:00 [pubmed]
PHST- 2005/02/09 09:00 [medline]
PHST- 2004/12/02 09:00 [entrez]
AID - 10.1007/s00268-004-7486-1 [doi]
PST - ppublish
SO  - World J Surg. 2004 Oct;28(10):1030-5. doi: 10.1007/s00268-004-7486-1. Epub 2004 
      Sep 29.