PMID- 15575346
OWN - NLM
STAT- MEDLINE
DCOM- 20050203
LR  - 20171116
IS  - 0394-3402 (Print)
IS  - 0394-3402 (Linking)
VI  - 17
IP  - 4
DP  - 2004 Aug
TI  - Expression of cell surface antigens in diabetic patients and healthy controls 
      after injury.
PG  - 244-6
AB  - AIMS: Due to the systemic character of Type 2 diabetes, cellular disturbances 
      paralleled by an altered expression of various growth factors constitute the 
      basis for impaired wound healing. Cell-surface antigens are altered in chronic 
      wounds and may also have an effect on the persistance of diabetic foot lesions. 
      METHODS: We investigated blood samples of diabetic patients with diabetic foot 
      ulcers (n=21) in comparison with those from healthy control patients subsequent 
      to an injury (n=9). A blood sample (EDTA) was taken from each participant (in the 
      trauma control group on the third day after injury) and examined by flow 
      cytometry [fluorescence-activated cell sorter (FACS)]. Typical cell surface 
      antigens involved in wound healing were studied [cluster of differentiation 
      (CD)2, CD3, CD4, CD25 and human leukocyte antigen (HLA)-diabetic retinopathy 
      (DR)]. RESULTS: known to adversely affect wound healing were elevated in diabetic 
      patients (CD2 p<0.001; CD3 p=0.016, CD4 p=0.22, CD25 p<0.001). HLA-DR expression 
      was also decreased in diabetic foot patients (p=0.023). CONCLUSIONS: Cell-surface 
      antigens appear to be altered in diabetic patients when compared to healthy 
      controls. Thus, due to the systemic character of Type 2 diabetes, cellular 
      disturbances may well constitute the basis for impaired wound healing in 
      diabetes.
FAU - Lobmann, R
AU  - Lobmann R
AD  - Department of Endocrinology and Metabolism, University of Magdeburg Medical 
      School, Magdeburg, Germany. ralf.lobmann@medizin.uni-magdeburg.de
FAU - Ittenson, A
AU  - Ittenson A
FAU - Schiweck, S
AU  - Schiweck S
FAU - Motzkau, M
AU  - Motzkau M
FAU - Schraven, B
AU  - Schraven B
FAU - Winckler, S
AU  - Winckler S
FAU - Lehnert, H
AU  - Lehnert H
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Diabetes Nutr Metab
JT  - Diabetes, nutrition & metabolism
JID - 8813443
RN  - 0 (Antigens, Differentiation, B-Lymphocyte)
RN  - 0 (Antigens, Differentiation, T-Lymphocyte)
RN  - 0 (CD2 Antigens)
RN  - 0 (CD3 Complex)
RN  - 0 (CD4 Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Receptors, Interleukin-2)
SB  - IM
MH  - Adult
MH  - Antigens, Differentiation, B-Lymphocyte/*blood/immunology
MH  - Antigens, Differentiation, T-Lymphocyte/*blood/immunology
MH  - CD2 Antigens/blood
MH  - CD3 Complex/blood
MH  - CD4 Antigens/blood
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/complications/*immunology
MH  - Diabetic Foot/*immunology/pathology
MH  - Female
MH  - Flow Cytometry
MH  - HLA-DR Antigens/blood
MH  - Humans
MH  - Leukocyte Count
MH  - Male
MH  - Middle Aged
MH  - Receptors, Interleukin-2/blood
MH  - Wound Healing/*immunology
MH  - Wounds and Injuries/immunology
EDAT- 2004/12/04 09:00
MHDA- 2005/02/04 09:00
CRDT- 2004/12/04 09:00
PHST- 2004/12/04 09:00 [pubmed]
PHST- 2005/02/04 09:00 [medline]
PHST- 2004/12/04 09:00 [entrez]
PST - ppublish
SO  - Diabetes Nutr Metab. 2004 Aug;17(4):244-6.