PMID- 15578167
OWN - NLM
STAT- MEDLINE
DCOM- 20050628
LR  - 20191210
IS  - 0014-4819 (Print)
IS  - 0014-4819 (Linking)
VI  - 162
IP  - 2
DP  - 2005 Apr
TI  - Processing of a simple aversive conditioned stimulus in a divided visual field 
      paradigm: an fMRI study.
PG  - 213-9
AB  - A left visual hemifield advantage for the processing of negative facial 
      expressions has been demonstrated in a variety of studies. We tested whether the 
      same effect is found for a neutral facial expression that had acquired a negative 
      meaning through pairing with an aversive event. Startle reflex amplitudes, 
      skin-conductance responses (SCR), and two verbal measures of affect (negative 
      valence and arousal) were significantly increased after pairing, but no 
      stimulation side by pairing interaction was observed. Functional magnetic 
      resonance imaging (fMRI) revealed a significant increase of BOLD (blood oxygen 
      level dependent) activity in the medial prefrontal cortex (MPFC), and the right 
      frontal opercular region (RFOP). MPFC activity was correlated with 
      psychophysiological and verbal emotional responses across subjects and, like 
      these responses, was independent of the stimulation side. In contrast, RFOP 
      activity was significantly stronger during left than during right hemifield 
      stimulation but did not correlate with psychophysiological or verbal measures of 
      negative affect. These results suggest that emotional responses to an aversive 
      conditioned expressively neutral face are similar in both visual hemifields. MPFC 
      activity seems to be closely linked to the strength of these responses.
FAU - Anders, Silke
AU  - Anders S
AD  - Institute of Medical Psychology and Behavioural Neurobiology, University of 
      Tubingen, Gartenstrasse 29, 72074, Tubingen, Germany. 
      silke.anders@med.uni-tuebingen.de
FAU - Lotze, Martin
AU  - Lotze M
FAU - Wildgruber, Dirk
AU  - Wildgruber D
FAU - Erb, Michael
AU  - Erb M
FAU - Grodd, Wolfgang
AU  - Grodd W
FAU - Birbaumer, Niels
AU  - Birbaumer N
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20041202
PL  - Germany
TA  - Exp Brain Res
JT  - Experimental brain research
JID - 0043312
SB  - IM
MH  - Adult
MH  - Avoidance Learning/*physiology
MH  - Conditioning, Psychological/*physiology
MH  - Female
MH  - Functional Laterality/*physiology
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Photic Stimulation/methods
MH  - Reflex, Startle/physiology
MH  - Visual Fields/*physiology
EDAT- 2004/12/04 09:00
MHDA- 2005/06/29 09:00
CRDT- 2004/12/04 09:00
PHST- 2004/06/01 00:00 [received]
PHST- 2004/09/09 00:00 [accepted]
PHST- 2004/12/04 09:00 [pubmed]
PHST- 2005/06/29 09:00 [medline]
PHST- 2004/12/04 09:00 [entrez]
AID - 10.1007/s00221-004-2145-1 [doi]
PST - ppublish
SO  - Exp Brain Res. 2005 Apr;162(2):213-9. doi: 10.1007/s00221-004-2145-1. Epub 2004 
      Dec 2.