PMID- 15579033
OWN - NLM
STAT- MEDLINE
DCOM- 20050307
LR  - 20190922
IS  - 1566-5240 (Print)
IS  - 1566-5240 (Linking)
VI  - 4
IP  - 8
DP  - 2004 Dec
TI  - Hereditary papillary renal carcinoma type I.
PG  - 855-68
AB  - Germline missense mutations in the tyrosine kinase domain of the hepatocyte 
      growth factor/scatter factor (HGF/SF) receptor, c-Met, are thought to be 
      responsible for hereditary papillary renal carcinoma (HPRC) type 1, a form of 
      human kidney cancer. In addition to extensive linkage analysis of HPRC families 
      localizing the HPRC type 1 gene within chromosome 7, the demonstration that 
      individual c-Met mutations reconstituted in cultured cells display enhanced and 
      dysregulated kinase activity, and confer cell transformation and tumorigenicity 
      in mice, solidifies this conclusion. Our prior knowledge of HGF/SF biology and 
      c-Met signaling enabled rapid progress in unraveling the molecular pathogenesis 
      of HPRC type 1, and in laying the framework for the development of novel 
      therapeutics for the treatment of this cancer. At the same time, the study of 
      HPRC type 1 has refined our appreciation of the oncogenic potential of c-Met 
      signaling, and challenges our current understanding of HGF/SF and c-Met function 
      in health and disease.
FAU - Dharmawardana, Pathirage G
AU  - Dharmawardana PG
AD  - Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, 
      National Institutes of Health, Bethesda, MD 20892-1501, USA.
FAU - Giubellino, Alessio
AU  - Giubellino A
FAU - Bottaro, Donald P
AU  - Bottaro DP
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Curr Mol Med
JT  - Current molecular medicine
JID - 101093076
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
SB  - IM
MH  - Carcinoma, Papillary/classification/*genetics
MH  - Cell Line, Tumor
MH  - Humans
MH  - Kidney Neoplasms/classification/*genetics
MH  - Mutation
MH  - Proto-Oncogene Proteins c-met/*genetics
RF  - 109
EDAT- 2004/12/08 09:00
MHDA- 2005/03/08 09:00
CRDT- 2004/12/08 09:00
PHST- 2004/12/08 09:00 [pubmed]
PHST- 2005/03/08 09:00 [medline]
PHST- 2004/12/08 09:00 [entrez]
AID - 10.2174/1566524043359674 [doi]
PST - ppublish
SO  - Curr Mol Med. 2004 Dec;4(8):855-68. doi: 10.2174/1566524043359674.