PMID- 15579644
OWN - NLM
STAT- MEDLINE
DCOM- 20050512
LR  - 20061115
IS  - 1066-5099 (Print)
IS  - 1066-5099 (Linking)
VI  - 22
IP  - 7
DP  - 2004
TI  - Simultaneous injection of bone marrow cells and stromal cells into bone marrow 
      accelerates hematopoiesis in vivo.
PG  - 1256-62
AB  - We have previously demonstrated that stromal cells can support the proliferation 
      and differentiation of hematopoietic cells in vitro and in vivo and that a major 
      histocompatibility complex restriction exists between hematopoietic stem cells 
      and stromal cells. We have also found that intra-bone marrow (IBM) injection of 
      allogeneic bone marrow cells (BMCs) leads to more rapid reconstitution of 
      hematopoietic cells than intravenous injection. In the present study, we examine 
      the effect of simultaneous injection of stromal cells and BMCs into the same bone 
      marrow on the recovery of donor hematopoietic cells and demonstrate that 
      simultaneous IBM injection of BMCs plus stromal cells is more effective in 
      reconstituting recipients with donor hematopoietic cells than intravenous 
      injection of BMCs plus stromal cells or IBM injection of BMCs alone.
FAU - Zhang, Yuming
AU  - Zhang Y
AD  - First Department of Pathology, Kansai Medical University, Moriguchi, Japan.
FAU - Adachi, Yasushi
AU  - Adachi Y
FAU - Suzuki, Yasuhiro
AU  - Suzuki Y
FAU - Minamino, Keizo
AU  - Minamino K
FAU - Iwasaki, Masayoshi
AU  - Iwasaki M
FAU - Hisha, Hiroko
AU  - Hisha H
FAU - Song, Chang Ye
AU  - Song CY
FAU - Kusafuka, Kimihide
AU  - Kusafuka K
FAU - Nakano, Keiji
AU  - Nakano K
FAU - Koike, Yasushi
AU  - Koike Y
FAU - Wang, Jianfeng
AU  - Wang J
FAU - Koh, Eitaku
AU  - Koh E
FAU - Cui, Yunze
AU  - Cui Y
FAU - Li, Chunfu
AU  - Li C
FAU - Ikehara, Susumu
AU  - Ikehara S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Stem Cells
JT  - Stem cells (Dayton, Ohio)
JID - 9304532
RN  - 0 (DNA Primers)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Bone Marrow Cells/*cytology
MH  - Bone Marrow Transplantation/*methods
MH  - Cell Differentiation
MH  - Cell Lineage
MH  - Cells, Cultured
MH  - Chondrocytes/metabolism
MH  - Cluster Analysis
MH  - DNA Primers/chemistry
MH  - Endothelium, Vascular/*cytology
MH  - Flow Cytometry
MH  - Gene Expression
MH  - Hematopoiesis
MH  - Humans
MH  - Leukocytes/metabolism
MH  - Mesoderm/*cytology
MH  - Neovascularization, Physiologic
MH  - Phylogeny
MH  - RNA, Messenger/metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Software
MH  - Stem Cells/*cytology
MH  - Stromal Cells/*cytology
MH  - Umbilical Cord/cytology
MH  - Umbilical Veins/*cytology
EDAT- 2004/12/08 09:00
MHDA- 2005/05/13 09:00
CRDT- 2004/12/08 09:00
PHST- 2004/12/08 09:00 [pubmed]
PHST- 2005/05/13 09:00 [medline]
PHST- 2004/12/08 09:00 [entrez]
AID - 22/7/1256 [pii]
AID - 10.1634/stemcells.2004-0173 [doi]
PST - ppublish
SO  - Stem Cells. 2004;22(7):1256-62. doi: 10.1634/stemcells.2004-0173.