PMID- 15581608
OWN - NLM
STAT- MEDLINE
DCOM- 20050215
LR  - 20131121
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 578
IP  - 1-2
DP  - 2004 Dec 3
TI  - Molecular signature associated with plasticity of bone marrow cell under 
      persistent liver damage by self-organizing-map-based gene expression.
PG  - 10-20
AB  - The mechanism that regulates the plasticity of bone marrow cells (BMCs) into 
      hepatocytes is poorly understood. We developed a green fluorescent protein/carbon 
      tetrachloride model to find that BMC transplantation recovered liver damage. 
      Serum albumin level and liver fibrosis were recovered by BMC transplantation. To 
      understand the mechanism, we used DNA-chip technology to profile the change of 
      transient gene expression before and after BMC transplantation. On the basis of 
      gene expression with self-organizing map using specific equation, genes were 
      classified into 153 clusters. The information is useful to understand the 
      dramatic gene activation during the process of the plasticity of BMC.
FAU - Omori, Kaoru
AU  - Omori K
AD  - Department of Molecular Science and Applied Medicine (Gastroenterology and 
      Hepatology), Yamaguchi University School of Medicine, Minami Kogushi 1-1-1, Ube, 
      Yamaguchi 755 8505, Japan.
FAU - Terai, Shuji
AU  - Terai S
FAU - Ishikawa, Tsuyoshi
AU  - Ishikawa T
FAU - Aoyama, Kouji
AU  - Aoyama K
FAU - Sakaida, Isao
AU  - Sakaida I
FAU - Nishina, Hiroshi
AU  - Nishina H
FAU - Shinoda, Koh
AU  - Shinoda K
FAU - Uchimura, Shunji
AU  - Uchimura S
FAU - Hamamoto, Yoshihiko
AU  - Hamamoto Y
FAU - Okita, Kiwamu
AU  - Okita K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 147336-22-9 (Green Fluorescent Proteins)
RN  - CL2T97X0V0 (Carbon Tetrachloride)
SB  - IM
MH  - Animals
MH  - Bone Marrow Cells/cytology/*physiology
MH  - Bone Marrow Transplantation
MH  - Carbon Tetrachloride/pharmacology/toxicity
MH  - Female
MH  - Fibrosis/chemically induced/therapy
MH  - *Gene Expression Profiling
MH  - *Gene Expression Regulation
MH  - Green Fluorescent Proteins/genetics/metabolism
MH  - Hepatocytes/cytology/physiology
MH  - Liver/drug effects/metabolism/*pathology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Molecular Sequence Data
MH  - Multigene Family
MH  - Oligonucleotide Array Sequence Analysis
MH  - Transcriptional Activation
EDAT- 2004/12/08 09:00
MHDA- 2005/02/16 09:00
CRDT- 2004/12/08 09:00
PHST- 2004/04/22 00:00 [received]
PHST- 2004/09/03 00:00 [revised]
PHST- 2004/09/23 00:00 [accepted]
PHST- 2004/12/08 09:00 [pubmed]
PHST- 2005/02/16 09:00 [medline]
PHST- 2004/12/08 09:00 [entrez]
AID - S0014579304013067 [pii]
AID - 10.1016/j.febslet.2004.09.090 [doi]
PST - ppublish
SO  - FEBS Lett. 2004 Dec 3;578(1-2):10-20. doi: 10.1016/j.febslet.2004.09.090.