PMID- 15581834
OWN - NLM
STAT- MEDLINE
DCOM- 20050512
LR  - 20041207
IS  - 0003-3995 (Print)
IS  - 0003-3995 (Linking)
VI  - 47
IP  - 4
DP  - 2004 Oct-Dec
TI  - Cryptic translocations involving chromosome 20 in polycythemia vera.
PG  - 365-71
AB  - A systematic cytogenetic study was performed in 49 patients with polycythemia 
      vera (PV) in order to investigate the occurrence of subtelomeric rearrangements 
      of chromosome 20, the most frequently rearranged chromosome in this 
      myeloproliferative disorder. Partial deletion of the long arm of chromosome 20 
      was observed in two patients and two cryptic translocations, t(1;20)(p36;q13) and 
      t(18;20)(p11;q13) in two others, all previously treated. The localization of the 
      breakpoints of the translocated 20 chromosomes was different in the two 
      translocations, as shown by fluorescence in situ hybridization (FISH) to 
      metaphase chromosomes using BAC clones. Although infrequent (2/49), cryptic 
      translocations of chromosome 20 deserve to be detected as preliminary to 
      identification of molecular defects in PV.
FAU - Busson, Maryvonne
AU  - Busson M
AD  - Inserm EMI 0210, Tour Pasteur, Hopital Necker-Enfants Malades, 149, rue de 
      Sevres, 75743 Paris cedex 15, France.
FAU - Romana, Serge
AU  - Romana S
FAU - Nguyen Khac, Florence
AU  - Nguyen Khac F
FAU - Bernard, Olivier
AU  - Bernard O
FAU - Berger, Roland
AU  - Berger R
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Ann Genet
JT  - Annales de genetique
JID - 0370562
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Chromosome Deletion
MH  - Chromosomes, Human, Pair 20/*genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Male
MH  - Middle Aged
MH  - Polycythemia Vera/*genetics
MH  - *Translocation, Genetic
EDAT- 2004/12/08 09:00
MHDA- 2005/05/13 09:00
CRDT- 2004/12/08 09:00
PHST- 2004/06/01 00:00 [received]
PHST- 2004/08/26 00:00 [accepted]
PHST- 2004/12/08 09:00 [pubmed]
PHST- 2005/05/13 09:00 [medline]
PHST- 2004/12/08 09:00 [entrez]
AID - S0003-3995(04)00080-2 [pii]
AID - 10.1016/j.anngen.2004.08.003 [doi]
PST - ppublish
SO  - Ann Genet. 2004 Oct-Dec;47(4):365-71. doi: 10.1016/j.anngen.2004.08.003.