PMID- 15582030
OWN - NLM
STAT- MEDLINE
DCOM- 20050512
LR  - 20131121
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 79
IP  - 3
DP  - 2004 Nov
TI  - Estrogen protects against brain lipid peroxidation in ethanol-withdrawn rats.
PG  - 573-86
AB  - This study examined whether 17beta-estradiol (E2) administration protects against 
      ethanol withdrawal (EW)-associated oxidative insults by assessing oxidative 
      markers thiobarbituric-acid-reacting-substances (TBARS). Ovariectomized rats 
      implanted with E2 (EW/E2) or oil pellets (EW/Oil) received chronic ethanol (7.5% 
      wt./vol., 5 weeks) or control dextrin diet (Dextrin/Oil). At 24 or 48 h of EW, 
      rats were tested for overt EW signs and the cerebellum, hippocampus, and cortex 
      were prepared for TBARS assessment in the presence and absence of FeCl3. For 
      control experiments, we assessed E2 effects on blood ethanol concentrations and 
      TBARS levels during ethanol exposure prior to EW. The EW/Oil group showed 
      enhanced endogenous- and FeCl3-stimulated membrane TBARS levels in the cerebellum 
      and hippocampus in a manner inhibited by E2 treatment. There was a relationship 
      between the severity of EW and elevation of TBARS levels, particularly in the 
      cerebellum. The enhanced TBARS levels at 24 h of EW appeared to diminish at 48 h 
      in the hippocampus, but persisted in the cerebellum. E2 treatment did not alter 
      blood ethanol concentrations and ethanol exposure alone did not enhance TBARS 
      levels. These data suggest that EW rather than ethanol enhances brain lipid 
      peroxidation that is transient and brain-region specific. Estrogens protect 
      against the brain lipid peroxidation in a manner independent of blood ethanol 
      concentrations.
FAU - Jung, Marianna E
AU  - Jung ME
AD  - Department of Pharmacology and Neuroscience, University of North Texas Health 
      Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 
      76107-2699, USA. mjung@hsc.unt.edu
FAU - Rewal, Mridula
AU  - Rewal M
FAU - Perez, Evelyn
AU  - Perez E
FAU - Wen, Yi
AU  - Wen Y
FAU - Simpkins, James W
AU  - Simpkins JW
LA  - eng
GR  - AA013864/AA/NIAAA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Estrogens)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Alcohol Drinking/drug therapy/metabolism
MH  - Animals
MH  - Brain/*drug effects/metabolism
MH  - Estrogens/*pharmacology/therapeutic use
MH  - Ethanol/*pharmacology
MH  - Female
MH  - Lipid Peroxidation/*drug effects/physiology
MH  - Ovariectomy
MH  - Rats
MH  - Substance Withdrawal Syndrome/*drug therapy/metabolism
EDAT- 2004/12/08 09:00
MHDA- 2005/05/13 09:00
CRDT- 2004/12/08 09:00
PHST- 2004/06/07 00:00 [received]
PHST- 2004/09/09 00:00 [revised]
PHST- 2004/09/10 00:00 [accepted]
PHST- 2004/12/08 09:00 [pubmed]
PHST- 2005/05/13 09:00 [medline]
PHST- 2004/12/08 09:00 [entrez]
AID - S0091-3057(04)00297-7 [pii]
AID - 10.1016/j.pbb.2004.09.007 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2004 Nov;79(3):573-86. doi: 10.1016/j.pbb.2004.09.007.