PMID- 15582284
OWN - NLM
STAT- MEDLINE
DCOM- 20050421
LR  - 20131121
IS  - 0531-5565 (Print)
IS  - 0531-5565 (Linking)
VI  - 39
IP  - 11-12
DP  - 2004 Nov-Dec
TI  - The Japanese quail: a model for studying reproductive aging of hypothalamic 
      systems.
PG  - 1679-93
AB  - During aging, the decline of neuroendocrine, endocrine, and behavioral components 
      of reproduction ultimately leads to reproductive failure. These studies 
      considered both neuroendocrine and behavioral aspects of reproductive aging in 
      Japanese quail, using chronological age and reproductive status to separate 
      animals into experimental groups. In Study I, age-related changes in the 
      gonadotropin releasing hormone (GnRH-I) system were investigated and a sharp 
      decrease was observed in GnRH-I concentration in the median eminence of aging 
      animals of both sexes, whereas preoptic-lateral septal region GnRH-I 
      concentrations declined only in aging males. Immunohistochemistry confirmed these 
      findings since aging females retained, whereas males lost GnRH-I cells. 
      Functional changes were assessed by in vitro incubation of parasaggittal 
      hypothalamic slices collected from young and old inactive males and females. 
      Results showed reduced baseline GnRH-I release and diminished response to 
      norepinephrine (NE). Deteriorating fertility also correlated with decreased male 
      sexual behavior and loss of aromatase immunoreactive (AROM-ir) neurons in the 
      medial, but not lateral preoptic nucleus (POA). Sexual behavior and AROM-ir were 
      restored with exogenous testosterone, which was associated with increased cell 
      size in the medial POA. Comparison of cell size and number of AROM-ir cells 
      showed that aged sexually active males had fewer, larger AROM-ir cells when 
      compared to young males, suggesting neuroplasticity of specific neural systems 
      and a critical role of estradiol in maintaining reproductive function.
FAU - Ottinger, Mary Ann
AU  - Ottinger MA
AD  - Department of Animal and Avian Sciences, University of Maryland, College Park, MD 
      20742, USA. maotting@umd.edu
FAU - Abdelnabi, Mahmoud
AU  - Abdelnabi M
FAU - Li, Qichang
AU  - Li Q
FAU - Chen, Kehong
AU  - Chen K
FAU - Thompson, Nicola
AU  - Thompson N
FAU - Harada, Nobuhiro
AU  - Harada N
FAU - Viglietti-Panzica, Carla
AU  - Viglietti-Panzica C
FAU - Panzica, Gian Carlo
AU  - Panzica GC
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
RN  - 0 (Neurotransmitter Agents)
RN  - 33515-09-2 (Gonadotropin-Releasing Hormone)
RN  - 3XMK78S47O (Testosterone)
RN  - EC 1.14.14.1 (Aromatase)
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Aromatase/metabolism
MH  - *Coturnix
MH  - Female
MH  - Gonadotropin-Releasing Hormone/metabolism
MH  - Hypothalamus/*metabolism
MH  - Male
MH  - Models, Animal
MH  - Neurotransmitter Agents/metabolism
MH  - Reproduction/*physiology
MH  - Sexual Behavior, Animal
MH  - Testosterone/metabolism
RF  - 84
EDAT- 2004/12/08 09:00
MHDA- 2005/04/22 09:00
CRDT- 2004/12/08 09:00
PHST- 2004/05/17 00:00 [received]
PHST- 2004/06/14 00:00 [accepted]
PHST- 2004/12/08 09:00 [pubmed]
PHST- 2005/04/22 09:00 [medline]
PHST- 2004/12/08 09:00 [entrez]
AID - S0531-5565(04)00283-9 [pii]
AID - 10.1016/j.exger.2004.06.021 [doi]
PST - ppublish
SO  - Exp Gerontol. 2004 Nov-Dec;39(11-12):1679-93. doi: 10.1016/j.exger.2004.06.021.