PMID- 15585330
OWN - NLM
STAT- MEDLINE
DCOM- 20050610
LR  - 20081121
IS  - 0165-2478 (Print)
IS  - 0165-2478 (Linking)
VI  - 96
IP  - 2
DP  - 2005 Jan 31
TI  - Interleukin IL-18 gene promoter polymorphisms in adult patients with type 1 
      diabetes mellitus and latent autoimmune diabetes in adults.
PG  - 247-51
AB  - Interleukin-18 (IL-18) gene promoter polymorphism is known as a genetic risk 
      factor for child type 1 diabetes mellitus development. To test the role of IL-18 
      gene polymorphism in predisposition to adult type 1 diabetes (T1DM) and latent 
      autoimmune diabetes in adults (LADA), we analysed SNPs at position -607 (C/A) and 
      -137 (G/C) in the promoter region of IL-18 gene by sequence-specific PCR in 49 
      T1DM, 66 LADA patients and 139 healthy controls. We found differences in allele, 
      genotype or haplotype distribution in tested patients when compared to 
      frequencies found in control group but these differences did not reach 
      statistical significance. However, there was a difference in -607 (C/A) allele 
      and genotype distribution found in LADA and T1DM patients that reached 
      statistical significance. These results suggest that the IL-18 gene promoter 
      polymorphisms are not associated with adult type 1 diabetes or LADA 
      susceptibility, and according to our findings genes involved in onset and 
      progression of LADA and T1DM are probably different.
FAU - Novota, Peter
AU  - Novota P
AD  - Department of Cell and Molecular Biology, The 3rd Faculty of Medicine, Charles 
      University, Ruska 87, 10021 Prague 10, Czech Republic. peter.novota@medicon.cz
FAU - Kolostova, Katarina
AU  - Kolostova K
FAU - Pinterova, Daniela
AU  - Pinterova D
FAU - Novak, Jan
AU  - Novak J
FAU - Treslova, Ludmila
AU  - Treslova L
FAU - Andel, Michal
AU  - Andel M
FAU - Cerna, Marie
AU  - Cerna M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Immunol Lett
JT  - Immunology letters
JID - 7910006
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adult
MH  - Czech Republic
MH  - Diabetes Mellitus, Type 1/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Haplotypes
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - Male
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic/*genetics
EDAT- 2004/12/09 09:00
MHDA- 2005/06/11 09:00
CRDT- 2004/12/09 09:00
PHST- 2004/06/08 00:00 [received]
PHST- 2004/08/26 00:00 [revised]
PHST- 2004/08/26 00:00 [accepted]
PHST- 2004/12/09 09:00 [pubmed]
PHST- 2005/06/11 09:00 [medline]
PHST- 2004/12/09 09:00 [entrez]
AID - S0165-2478(04)00238-X [pii]
AID - 10.1016/j.imlet.2004.08.016 [doi]
PST - ppublish
SO  - Immunol Lett. 2005 Jan 31;96(2):247-51. doi: 10.1016/j.imlet.2004.08.016.