PMID- 15585759
OWN - NLM
STAT- MEDLINE
DCOM- 20050106
LR  - 20230318
IS  - 0002-9165 (Print)
IS  - 0002-9165 (Linking)
VI  - 80
IP  - 6
DP  - 2004 Dec
TI  - Butter and walnuts, but not olive oil, elicit postprandial activation of nuclear 
      transcription factor kappaB in peripheral blood mononuclear cells from healthy 
      men.
PG  - 1487-91
AB  - BACKGROUND: Nuclear transcription factor kappaB (NF-kappaB) plays an important 
      role in atherosclerosis by modulating gene expression. Postprandial lipemia has 
      been correlated with an increase in NF-kappaB activation in vascular cells and it 
      is associated with an increase in postprandial triacylglycerol-rich lipoproteins, 
      which are involved in the development of atherosclerotic plaque. OBJECTIVE: The 
      objective of this study was to determine the effect of the intakes of 3 different 
      foods with different fat compositions on the postprandial activation of monocyte 
      NF-kappaB. DESIGN: Eight healthy men followed a 4-wk baseline diet and then 
      consumed 3 fat-load meals consisting of 1 g fat/kg body wt (65% fat) according to 
      a randomized crossover design. Each meal had a different fatty acid composition, 
      and the consumption of each meal was separated by 1 wk. The compositions of the 3 
      test meals were as follows: olive oil meal [22% saturated fatty acids (SFAs), 38% 
      monounsaturated fatty acids (MUFAs), 4% polyunsaturated fatty acids (PUFAs), and 
      0.7% alpha-linolenic acid], butter meal (38% SFAs, 22% MUFAs, 4% PUFAs, and 0.7% 
      alpha-linolenic acid), and walnut meal (20% SFAs, 24% MUFAs, 16% PUFAs, and 4% 
      alpha-linolenic acid). RESULTS: Ingestion of the olive oil meal did not elicit 
      NF-kappaB activation compared with ingestion of either the butter meal at 3 h (P 
      <0.05) or the walnut meal at 9 h (P <0.05). There was no significant difference 
      in the postprandial triacylglycerol response between the 3 meals. CONCLUSIONS: 
      Consumption of an olive oil-enriched meal does not activate NF-kappaB in 
      monocytes as do butter and walnut-enriched meals. This effect could enhance the 
      cardioprotective effect of olive oil-enriched diets.
FAU - Bellido, Cecilia
AU  - Bellido C
AD  - Lipids and Arteriosclerosis Unit, Hospital Universitario Reina Sofia, Cordoba, 
      Spain.
FAU - Lopez-Miranda, Jose
AU  - Lopez-Miranda J
FAU - Blanco-Colio, Luis Miguel
AU  - Blanco-Colio LM
FAU - Perez-Martinez, Pablo
AU  - Perez-Martinez P
FAU - Muriana, Francisco Jose
AU  - Muriana FJ
FAU - Martin-Ventura, Jose Luis
AU  - Martin-Ventura JL
FAU - Marin, Carmen
AU  - Marin C
FAU - Gomez, Purificacion
AU  - Gomez P
FAU - Fuentes, Francisco
AU  - Fuentes F
FAU - Egido, Jesus
AU  - Egido J
FAU - Perez-Jimenez, Francisco
AU  - Perez-Jimenez F
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Clin Nutr
JT  - The American journal of clinical nutrition
JID - 0376027
RN  - 0 (Dietary Fats)
RN  - 0 (Fatty Acids)
RN  - 0 (Fatty Acids, Monounsaturated)
RN  - 0 (Fatty Acids, Unsaturated)
RN  - 0 (Lipids)
RN  - 0 (NF-kappa B)
RN  - 0 (Olive Oil)
RN  - 0 (Plant Oils)
RN  - 0 (Triglycerides)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 8029-34-3 (Butter)
SB  - IM
MH  - Arteriosclerosis/metabolism/prevention & control
MH  - *Butter
MH  - Cross-Over Studies
MH  - Dietary Fats/*administration & dosage
MH  - Fatty Acids/administration & dosage
MH  - Fatty Acids, Monounsaturated/administration & dosage
MH  - Fatty Acids, Unsaturated/administration & dosage
MH  - Gene Expression Regulation
MH  - Humans
MH  - Intercellular Adhesion Molecule-1/blood
MH  - *Juglans
MH  - Leukocytes, Mononuclear/*metabolism
MH  - Lipids/blood
MH  - Male
MH  - NF-kappa B/blood/*metabolism
MH  - Olive Oil
MH  - Plant Oils
MH  - *Postprandial Period
MH  - Triglycerides/blood/chemistry
EDAT- 2004/12/09 09:00
MHDA- 2005/01/07 09:00
CRDT- 2004/12/09 09:00
PHST- 2004/12/09 09:00 [pubmed]
PHST- 2005/01/07 09:00 [medline]
PHST- 2004/12/09 09:00 [entrez]
AID - S0002-9165(22)03731-5 [pii]
AID - 10.1093/ajcn/80.6.1487 [doi]
PST - ppublish
SO  - Am J Clin Nutr. 2004 Dec;80(6):1487-91. doi: 10.1093/ajcn/80.6.1487.