PMID- 15592842
OWN - NLM
STAT- MEDLINE
DCOM- 20050711
LR  - 20201226
IS  - 0344-4325 (Print)
IS  - 0344-4325 (Linking)
VI  - 26
IP  - 3
DP  - 2005 Jan
TI  - Pathways for antigen cross presentation.
PG  - 257-71
AB  - Dendritic cells (DCs) have the unique ability to capture cellular tissue 
      antigens, and to present them on MHC class I molecules to antigen-specific CD8(+) 
      T lymphocytes after migration to the draining lymph nodes. This process, called 
      "cross presentation" can lead either to the tolerization or activation of 
      antigen-specific CD8(+) T cells. Antigen capture is believed to occur by 
      phagocytosis of antigen-bearing dead cells. Recent studies suggest that the 
      antigen transferred from the phagocytosed cell to the DC during cross 
      presentation is a proteasome substrate, rather than a proteasomal degradation 
      product. In most cases, the formation of the peptide-MHC class I complexes in DCs 
      requires the export of protein antigens from phagosomes to the cytosol, where 
      they undergo proteasomal degradation. The resulting peptides are then 
      translocated by TAP to the lumen of a cross presentation-loading compartment, for 
      association to MHC class I under the control of chaperones and oxido-reductases. 
      This loading compartment may be either the endoplasmic reticulum (ER) or a mix 
      phagosome-ER compartment. MHC class I egress from the loading compartment to cell 
      surface remains to be analyzed.
FAU - Guermonprez, Pierre
AU  - Guermonprez P
AD  - U365 INSERM, Institut Curie, 26 rue d'Ulm, 75005 Paris, France. 
      sebastian.amigorena@curie.fr
FAU - Amigorena, Sebastian
AU  - Amigorena S
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20041203
PL  - Germany
TA  - Springer Semin Immunopathol
JT  - Springer seminars in immunopathology
JID - 7910384
RN  - 0 (Heat-Shock Proteins)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - EC 3.4.25.1 (Proteasome Endopeptidase Complex)
SB  - IM
MH  - Animals
MH  - *Antigen Presentation
MH  - Apoptosis
MH  - CD8-Positive T-Lymphocytes/immunology
MH  - Dendritic Cells/immunology
MH  - Endoplasmic Reticulum/immunology
MH  - Heat-Shock Proteins/immunology
MH  - Histocompatibility Antigens Class I/metabolism
MH  - Humans
MH  - Membrane Fusion
MH  - Phagosomes/immunology
MH  - Proteasome Endopeptidase Complex/metabolism
RF  - 93
EDAT- 2004/12/14 09:00
MHDA- 2005/07/12 09:00
CRDT- 2004/12/14 09:00
PHST- 2004/08/15 00:00 [received]
PHST- 2004/08/15 00:00 [accepted]
PHST- 2004/12/14 09:00 [pubmed]
PHST- 2005/07/12 09:00 [medline]
PHST- 2004/12/14 09:00 [entrez]
AID - 10.1007/s00281-004-0176-0 [doi]
PST - ppublish
SO  - Springer Semin Immunopathol. 2005 Jan;26(3):257-71. doi: 
      10.1007/s00281-004-0176-0. Epub 2004 Dec 3.