PMID- 15593383
OWN - NLM
STAT- MEDLINE
DCOM- 20050308
LR  - 20181113
IS  - 1673-1581 (Print)
IS  - 1673-1581 (Linking)
VI  - 6
IP  - 1
DP  - 2005 Jan
TI  - On dendritic cell-based therapy for cancers.
PG  - 1-3
AB  - Dendritic cells (DCs), the most prevalent antigen-presenting cell in vivo, had 
      been widely characterized in the last three decades. DCs are present in almost 
      all tissues of the body and play cardinal roles in recognition of microbial 
      agents, autoantigens, allergens and alloantigen. DCs process the microbial agents 
      or their antigens and migrate to lymphoid tissues to present the antigenic 
      peptide to lymphocytes. This leads to activation of antigen-specific lymphocytes. 
      Initially, it was assumed that DCs are principally involved in the induction and 
      maintenance of adaptive immune responses, but now it is evident that DCs also 
      have important roles in innate immunity. These features make DCs very good 
      candidates for therapy against various pathological conditions including 
      malignancies. Initially, DC-based therapy was used in animal models of cancers. 
      Data from these studies inspired considerable optimism and DC-based therapies was 
      started in human cancers 8 years ago. In general, DC-based therapy has been found 
      to be safe in patients with cancers, although few controlled trials have been 
      conducted in this regard. Because, the fundamentals principles of human cancers 
      and animal models of cancers are different, the therapeutic efficacy of the 
      ongoing regime of DC-based therapy in cancer patients is not satisfactory. In 
      this review, we covered the various aspects that should be considered for 
      developing better regime of DC-based therapy for human cancers.
FAU - Onji, Morikazu
AU  - Onji M
AD  - Third Department of Internal Medicine, School of Medicine, Ehime University, 
      Ehime, Japan.
FAU - Akbar, Sk Md Fazle
AU  - Akbar SM
LA  - eng
PT  - Journal Article
PT  - Review
PL  - China
TA  - J Zhejiang Univ Sci B
JT  - Journal of Zhejiang University. Science. B
JID - 101236535
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology/*transplantation
MH  - Disease Models, Animal
MH  - Humans
MH  - Neoplasms/*immunology/*therapy
MH  - Vaccination/*methods
PMC - PMC1390750
EDAT- 2004/12/14 09:00
MHDA- 2005/03/09 09:00
PMCR- 2005/01/01
CRDT- 2004/12/14 09:00
PHST- 2004/12/14 09:00 [pubmed]
PHST- 2005/03/09 09:00 [medline]
PHST- 2004/12/14 09:00 [entrez]
PHST- 2005/01/01 00:00 [pmc-release]
AID - 10.1631/jzus.2005.B0001 [doi]
PST - ppublish
SO  - J Zhejiang Univ Sci B. 2005 Jan;6(1):1-3. doi: 10.1631/jzus.2005.B0001.