PMID- 15596127
OWN - NLM
STAT- MEDLINE
DCOM- 20050321
LR  - 20161020
IS  - 1286-4579 (Print)
IS  - 1286-4579 (Linking)
VI  - 6
IP  - 15
DP  - 2004 Dec
TI  - Dendritic cells in Leishmania infection.
PG  - 1402-9
AB  - Dendritic cells (DCs) are key elements of the immune system, which function as 
      sentinel in the periphery and alert T lymphocytes about the type of invading 
      antigen and address their polarisation, in order to mount an efficacious immune 
      response. Leishmania spp. are parasitic protozoa which may cause severe disease 
      in humans and domestic animals. In this work, the main studies concerning the 
      role of DCs in Leishmania infection are reviewed, in both the murine and human 
      models. In particular, the importance of the genetic status of the hosts and of 
      the different Leishmania species in modulating DC-mediated immune response is 
      examined. In addition, different approaches of DC-based vaccination against 
      experimental leishmaniasis, which could have important future applications, are 
      summarised.
FAU - Brandonisio, Olga
AU  - Brandonisio O
AD  - Department of Internal Medicine, Immunology and Infectious Diseases, University 
      of Bari Medical School, Bari, Italy. brandonisio@midim.uniba.it
FAU - Spinelli, Rosa
AU  - Spinelli R
FAU - Pepe, Maria
AU  - Pepe M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - France
TA  - Microbes Infect
JT  - Microbes and infection
JID - 100883508
RN  - 0 (Protozoan Vaccines)
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology/parasitology
MH  - Humans
MH  - Leishmania major/*immunology
MH  - Leishmaniasis, Cutaneous/immunology/*prevention & control
MH  - Protozoan Vaccines/administration & dosage/*immunology
MH  - Vaccination
RF  - 65
EDAT- 2004/12/15 09:00
MHDA- 2005/03/22 09:00
CRDT- 2004/12/15 09:00
PHST- 2004/12/15 09:00 [pubmed]
PHST- 2005/03/22 09:00 [medline]
PHST- 2004/12/15 09:00 [entrez]
AID - S1286-4579(04)00305-3 [pii]
AID - 10.1016/j.micinf.2004.10.004 [doi]
PST - ppublish
SO  - Microbes Infect. 2004 Dec;6(15):1402-9. doi: 10.1016/j.micinf.2004.10.004.