PMID- 15598144
OWN - NLM
STAT- MEDLINE
DCOM- 20050214
LR  - 20131121
IS  - 0735-7044 (Print)
IS  - 0735-7044 (Linking)
VI  - 118
IP  - 6
DP  - 2004 Dec
TI  - Testosterone's analgesic, anxiolytic, and cognitive-enhancing effects may be due 
      in part to actions of its 5alpha-reduced metabolites in the hippocampus.
PG  - 1352-64
AB  - Although testosterone (T) may decrease anxiety and enhance cognitive performance, 
      its mechanisms are not well understood. The authors hypothesized that if T's 
      effects are mediated in part through actions of its 5alpha-reduced, 
      nonaromatizable metabolite dihydrotestosterone (DHT) and/or its 
      3alpha-hydroxysteroid dehydrogenase reduced metabolite 3alpha-androstanediol 
      (3alpha-diol) in the hippocampus, then T, DHT, and 3alpha-diol administration 
      should produce similar behavioral effects concomitant with elevating T 
      metabolites in the hippocampus. Gonadectomized male rats administered T, DHT, or 
      3alpha-diol via Silastic capsules or intrahippocampal infusions had greater 
      analgesia (tail flick, paw lick), less anxiety behavior (plus-maze, open field, 
      defensive freezing), and better learning (inhibitory avoidance) compared with 
      vehicle control rats. Only 3alpha-diol levels in the hippocampus were 
      consistently elevated in conjunction with these behavioral effects.
FAU - Edinger, Kassandra L
AU  - Edinger KL
AD  - Department of Psychology, The University at Albany-SUNY, Albany, NY 12222, USA.
FAU - Frye, Cheryl A
AU  - Frye CA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Behav Neurosci
JT  - Behavioral neuroscience
JID - 8302411
RN  - 08J2K08A3Y (Dihydrotestosterone)
RN  - 3XMK78S47O (Testosterone)
RN  - EC 1.1.1.50 (3-alpha-Hydroxysteroid Dehydrogenase (B-Specific))
SB  - IM
MH  - 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)/administration & dosage
MH  - *Analgesia
MH  - Analysis of Variance
MH  - Animals
MH  - Anxiety/*drug therapy
MH  - Avoidance Learning/drug effects
MH  - Behavior, Animal
MH  - Cognition/*drug effects/physiology
MH  - Dihydrotestosterone/administration & dosage
MH  - Drug Administration Routes
MH  - Exploratory Behavior/drug effects
MH  - Hippocampus/*drug effects/physiology
MH  - Male
MH  - Maze Learning/drug effects
MH  - Models, Biological
MH  - Models, Chemical
MH  - Orchiectomy
MH  - Pain Measurement/drug effects
MH  - Radioimmunoassay/methods
MH  - Rats
MH  - Rats, Long-Evans
MH  - Reaction Time/drug effects
MH  - Testosterone/*pharmacology
EDAT- 2004/12/16 09:00
MHDA- 2005/02/16 09:00
CRDT- 2004/12/16 09:00
PHST- 2004/12/16 09:00 [pubmed]
PHST- 2005/02/16 09:00 [medline]
PHST- 2004/12/16 09:00 [entrez]
AID - 2004-21410-021 [pii]
AID - 10.1037/0735-7044.118.6.1352 [doi]
PST - ppublish
SO  - Behav Neurosci. 2004 Dec;118(6):1352-64. doi: 10.1037/0735-7044.118.6.1352.