PMID- 15598642
OWN - NLM
STAT- MEDLINE
DCOM- 20050315
LR  - 20051116
IS  - 1524-4539 (Electronic)
IS  - 0009-7322 (Linking)
VI  - 110
IP  - 24 Suppl 1
DP  - 2004 Dec 14
TI  - Preventing venous thromboembolism in medical patients.
PG  - IV13-9
AB  - Given the increased number of patients hospitalized for acute medical illnesses 
      and the associated risk of venous thromboembolism (VTE), the use of prophylaxis 
      has become a public health matter. Thromboprophylaxis is not widely practiced in 
      acutely ill medical patients, due in part to the heterogeneity of this group and 
      the perceived difficulty in assessing those who would most benefit from 
      treatment. Nevertheless, the results of recent well-conducted clinical trials 
      support the evidence-based recommendations for more widespread systematic use of 
      low-dose low-molecular-weight heparin (LMWH) or unfractionated heparin (UFH) in 
      this population. Three large well-controlled studies (MEDENOX, PREVENT, and 
      ARTEMIS) in acutely ill medical patients confirm previous findings that different 
      at-risk patient populations show a consistent 50% reduction in VTE events with 
      LMWH and fondaparinux. A meta-analysis in nearly 5000 patients in internal 
      medicine comparing UFH and LMWH revealed a trend for reduction of deep vein 
      thrombosis and pulmonary embolism with LMWH. Based on duration of use in clinical 
      trials in acutely ill medical patients, prophylactic treatment with UFH and LMWH 
      is recommended for 2 weeks.
FAU - Leizorovicz, Alain
AU  - Leizorovicz A
AD  - Unite de Pharmacologie Clinique, EA 3736, Universite Claude Bernard Lyon I, Rue 
      Guillaume Paradin, 69376 Lyon Cedex 08, France. al@upcl.univ-lyon1.fr
FAU - Mismetti, Patrick
AU  - Mismetti P
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Circulation
JT  - Circulation
JID - 0147763
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Heparin/therapeutic use
MH  - Hospitalization
MH  - Humans
MH  - Patient Selection
MH  - Pulmonary Embolism/epidemiology/etiology/*prevention & control
MH  - Risk Factors
MH  - Venous Thrombosis/epidemiology/etiology/*prevention & control
RF  - 42
EDAT- 2004/12/16 09:00
MHDA- 2005/03/16 09:00
CRDT- 2004/12/16 09:00
PHST- 2004/12/16 09:00 [pubmed]
PHST- 2005/03/16 09:00 [medline]
PHST- 2004/12/16 09:00 [entrez]
AID - 110/24_suppl_1/IV-13 [pii]
AID - 10.1161/01.CIR.0000150640.98772.af [doi]
PST - ppublish
SO  - Circulation. 2004 Dec 14;110(24 Suppl 1):IV13-9. doi: 
      10.1161/01.CIR.0000150640.98772.af.