PMID- 15600237
OWN - NLM
STAT- MEDLINE
DCOM- 20050304
LR  - 20061115
IS  - 1472-4472 (Print)
IS  - 1472-4472 (Linking)
VI  - 5
IP  - 8
DP  - 2004 Aug
TI  - Structure-activity relationship analysis and therapeutic potential of peptide 
      deformylase inhibitors.
PG  - 809-22
AB  - Peptide deformylase inhibitors (PDFIs) appear to be one of the most exciting 
      classes of antibacterial agents discovered to date. Rapid progress in the 
      development of PDFIs has been possible because peptide deformylase is a 
      metalloprotease, and this class of enzymes shows a high degree of 
      structure-function conservation, and because the most potent PDFIs are 
      hydroxamate derivatives, a well known category of pharmacophores. The current 
      challenge in structure-activity relationship analysis is obtaining molecules with 
      potent in vivo antibacterial activity against a range of drug-resistant 
      pathogens. The PDFIs currently in clinical trials target community-based 
      bacterial infections, with a potential major pharmaceutical market.
FAU - Boularot, Adrien
AU  - Boularot A
AD  - Centre National de la Recherche Scientifique, Protein Maturation Group, Institut 
      des Sciences du Vegetal, UPR2355, Batiment 23, 1 avenue de la Terrasse, F-91198 
      Gif-sur-Yvette, France.
FAU - Giglione, Carmela
AU  - Giglione C
FAU - Artaud, Isabelle
AU  - Artaud I
FAU - Meinnel, Thierry
AU  - Meinnel T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Curr Opin Investig Drugs
JT  - Current opinion in investigational drugs (London, England : 2000)
JID - 100965718
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Chelating Agents)
RN  - 0 (Enzyme Inhibitors)
RN  - EC 3.5.- (Amidohydrolases)
RN  - EC 3.5.1.88 (peptide deformylase)
SB  - IM
MH  - Amidohydrolases/*antagonists & inhibitors/metabolism
MH  - Animals
MH  - Anti-Bacterial Agents/*pharmacology
MH  - Chelating Agents/pharmacology
MH  - Drug Resistance, Bacterial
MH  - Enzyme Inhibitors/chemistry/*pharmacology
MH  - Humans
MH  - Molecular Conformation
MH  - Structure-Activity Relationship
RF  - 126
EDAT- 2004/12/17 09:00
MHDA- 2005/03/05 09:00
CRDT- 2004/12/17 09:00
PHST- 2004/12/17 09:00 [pubmed]
PHST- 2005/03/05 09:00 [medline]
PHST- 2004/12/17 09:00 [entrez]
PST - ppublish
SO  - Curr Opin Investig Drugs. 2004 Aug;5(8):809-22.