PMID- 15601619
OWN - NLM
STAT- MEDLINE
DCOM- 20050715
LR  - 20161124
IS  - 0898-6568 (Print)
IS  - 0898-6568 (Linking)
VI  - 17
IP  - 4
DP  - 2005 Apr
TI  - Soluble guanylyl cyclase: more secrets revealed.
PG  - 407-13
AB  - Guanylyl cyclases (GCs) are enzymes that convert guanosine-5'-triphosphate (GTP) 
      to cyclic guanosine-3',5'-monophosphate (cGMP). The second messenger cGMP 
      participates in signaling by (1) stimulating the activity of kinases that belong 
      to the protein kinase G family, (2) altering the conductance of cGMP-gated ion 
      channels and (3) changing the activity of cGMP-regulated phosphodiesterases. In 
      contrast to adenylyl cyclases which exist as membrane-bound molecules, guanylyl 
      cyclases (GC) occur in both membrane-bound and cytosolic forms. The particulate 
      GC (pGC) isoforms serve as receptors for natriuretic peptides, while soluble GC 
      (sGC) is the "receptor" for nitric oxide (NO). In addition to the difference in 
      ligands and subcellular organization, the two forms of GC also differ in that pGC 
      exists in homodimeric form, while typically sGC occurs as a heterodimer. Herein, 
      we will review the literature on sGC subunit structure and discuss the regulation 
      of the enzyme at the transcriptional and post-translational level.
FAU - Pyriochou, Anastasia
AU  - Pyriochou A
AD  - Laboratory for Molecular Pharmacology, School of Pharmacy, University of Patras, 
      26504 Patras, Greece.
FAU - Papapetropoulos, Andreas
AU  - Papapetropoulos A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Cell Signal
JT  - Cellular signalling
JID - 8904683
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - EC 4.6.1.2 (Guanylate Cyclase)
RN  - EC 4.6.1.2 (Soluble Guanylyl Cyclase)
SB  - IM
MH  - Animals
MH  - Dimerization
MH  - Guanylate Cyclase
MH  - Humans
MH  - Protein Processing, Post-Translational
MH  - Receptors, Cytoplasmic and Nuclear/*chemistry/*metabolism
MH  - Soluble Guanylyl Cyclase
MH  - Transcription, Genetic
RF  - 81
EDAT- 2004/12/17 09:00
MHDA- 2005/07/16 09:00
CRDT- 2004/12/17 09:00
PHST- 2004/08/11 00:00 [received]
PHST- 2004/09/10 00:00 [accepted]
PHST- 2004/12/17 09:00 [pubmed]
PHST- 2005/07/16 09:00 [medline]
PHST- 2004/12/17 09:00 [entrez]
AID - S0898-6568(04)00197-4 [pii]
AID - 10.1016/j.cellsig.2004.09.008 [doi]
PST - ppublish
SO  - Cell Signal. 2005 Apr;17(4):407-13. doi: 10.1016/j.cellsig.2004.09.008.