PMID- 15603363 OWN - NLM STAT- MEDLINE DCOM- 20050420 LR - 20171116 IS - 1426-9686 (Print) IS - 1426-9686 (Linking) VI - 17 Suppl 1 DP - 2004 TI - [CD11b and CD62L receptors expression on neutrophils after laparoscopic versus open cholecystectomy]. PG - 101-4 AB - The development of immunology correlated with surgery enables close recognition of multiple mechanisms responsible for more frequent complications observed after open surgical procedures than after minimally invasive operations. OBJECTIVE: Evaluation of selected elements of non-specific immunity in patients undergoing open cholecystectomy (OC) versus laparoscopic cholecystectomy (LC). MATERIAL AND METHODS: 30 postmenopausal females with non-complicated cholecystolithiasis were analysed. Both OC and LC was performed in 15 cases. Blood samples for an analysis were collected 24 hours before surgery and 24 and 72 hours postoperatively. Qualitative changes of neutrophils measured by the expression of CD11b and CD62L receptors on their surface without or with formyl-methionyl-leucyl-phenylalanine (fMLP) stimulation were evaluated. RESULTS: The expression of CD11b and CD62L receptors show no significant changes in patients that underwent LC while patients that underwent OC had significant changes 24 hours postoperatively compared both with their preoperative values and values observed in patients after LC. CONCLUSION: The activation of neutrophils measured by changes of the expression of CD11b and CD62L receptors on their surface is connected with the magnitude of trauma and is only observed in patients after OC. FAU - Kordiak, Jacek AU - Kordiak J AD - Klinika Chirurgii Ogolnej i Torakochirurgii UM w Lodzi. jkordiak@interia.pl FAU - Bella, Mariusz AU - Bella M FAU - Rysz, Jacek AU - Rysz J FAU - Jablonski, Slawomir AU - Jablonski S FAU - Brocki, Marian AU - Brocki M FAU - Kowalska, Barbara AU - Kowalska B FAU - Kutwin, Leszek AU - Kutwin L FAU - Niemirowicz, Maciej AU - Niemirowicz M FAU - Gruda, Robert AU - Gruda R FAU - Wcislo, Szymon AU - Wcislo S LA - pol PT - Comparative Study PT - Journal Article TT - Ekspresja receptorow CD11b i CD62L na powierzchni neutrofilow obojetnochlonnych po cholecystektomii laparoskopowej w porownaniu z cholecystektomia klasyczna. PL - Poland TA - Pol Merkur Lekarski JT - Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego JID - 9705469 RN - 0 (CD11b Antigen) RN - 126880-86-2 (L-Selectin) SB - IM MH - Aged MH - CD11b Antigen/immunology/*metabolism MH - Cholecystectomy, Laparoscopic/*methods MH - Cholecystolithiasis/immunology/*metabolism/*surgery MH - Female MH - Humans MH - L-Selectin/immunology/*metabolism MH - Middle Aged MH - Neutrophils/immunology/*metabolism MH - *Postoperative Care MH - Prospective Studies EDAT- 2004/12/18 09:00 MHDA- 2005/04/21 09:00 CRDT- 2004/12/18 09:00 PHST- 2004/12/18 09:00 [pubmed] PHST- 2005/04/21 09:00 [medline] PHST- 2004/12/18 09:00 [entrez] PST - ppublish SO - Pol Merkur Lekarski. 2004;17 Suppl 1:101-4.