PMID- 15603816
OWN - NLM
STAT- MEDLINE
DCOM- 20050629
LR  - 20181201
IS  - 0142-9612 (Print)
IS  - 0142-9612 (Linking)
VI  - 26
IP  - 16
DP  - 2005 Jun
TI  - In vitro degradation of porous poly(propylene 
      fumarate)/poly(DL-lactic-co-glycolic acid) composite scaffolds.
PG  - 3215-25
AB  - This study investigated the in vitro degradation of porous poly(propylene 
      fumarate) (PPF-based) composites incorporating microparticles of blends of 
      poly(DL-lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) during a 
      26-week period in pH 7.4 phosphate-buffered saline at 37 degrees C. Using a 
      fractional factorial design, four formulations of composite scaffolds were 
      fabricated with varying PEG content of the microparticles, microparticle mass 
      fraction of the composite material, and initial leachable porogen content of the 
      scaffold formulations. PPF scaffolds without microparticles were fabricated with 
      varying leachable porogen content for use as controls. The effects of including 
      PLGA/PEG microparticles in PPF scaffolds and the influence of alterations in the 
      composite formulation on scaffold mass, geometry, water absorption, mechanical 
      properties and porosity were examined for cylindrical specimens with lengths of 
      13 mm and diameters of 6.5 mm. The composite scaffold composition affected the 
      extent of loss of polymer mass, scaffold length, and diameter, with the greatest 
      loss of polymer mass equal to 15+/-5% over 26 weeks. No formulation, however, 
      exhibited any variation in compressive modulus or peak compressive strength over 
      time. Additionally, sample porosity, as determined by both mercury porosimetry 
      and micro-computed tomography did not change during the period of this study. 
      These results demonstrate that microparticle carriers can be incorporated into 
      PPF scaffolds for localized delivery of bioactive molecules without altering 
      scaffold mechanical or structural properties up to 26 weeks in vitro.
FAU - Hedberg, Elizabeth L
AU  - Hedberg EL
AD  - Department of Bioengineering, Rice University, P.O. Box 1892-MS 142, Houston, TX 
      77251-1892, USA.
FAU - Shih, Charles K
AU  - Shih CK
FAU - Lemoine, Jeremy J
AU  - Lemoine JJ
FAU - Timmer, Mark D
AU  - Timmer MD
FAU - Liebschner, Michael A K
AU  - Liebschner MA
FAU - Jansen, John A
AU  - Jansen JA
FAU - Mikos, Antonios G
AU  - Mikos AG
LA  - eng
GR  - R01-AR42639/AR/NIAMS NIH HHS/United States
GR  - R01-DE15164/DE/NIDCR NIH HHS/United States
GR  - T32-GM08362/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Biomaterials
JT  - Biomaterials
JID - 8100316
RN  - 0 (Biocompatible Materials)
RN  - 0 (Fumarates)
RN  - 0 (Glycolates)
RN  - 0 (Polymers)
RN  - 0 (Polypropylenes)
RN  - 0 (poly(propylene fumarate))
RN  - 059QF0KO0R (Water)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - FXS1BY2PGL (Mercury)
SB  - IM
MH  - Biocompatible Materials/*chemistry
MH  - Fumarates/*chemistry
MH  - Glycolates/*chemistry
MH  - Hydrogen-Ion Concentration
MH  - Lactic Acid/chemistry
MH  - Materials Testing
MH  - Mercury/chemistry
MH  - Microcirculation
MH  - Microscopy, Electron, Scanning
MH  - Polyethylene Glycols/chemistry
MH  - Polyglycolic Acid/chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Polymers/chemistry
MH  - Polypropylenes/*chemistry
MH  - Temperature
MH  - Time Factors
MH  - Tissue Engineering
MH  - Tomography, X-Ray Computed
MH  - Water/chemistry
EDAT- 2004/12/18 09:00
MHDA- 2005/06/30 09:00
CRDT- 2004/12/18 09:00
PHST- 2004/08/20 00:00 [received]
PHST- 2004/09/09 00:00 [accepted]
PHST- 2004/12/18 09:00 [pubmed]
PHST- 2005/06/30 09:00 [medline]
PHST- 2004/12/18 09:00 [entrez]
AID - S0142-9612(04)00809-9 [pii]
AID - 10.1016/j.biomaterials.2004.09.012 [doi]
PST - ppublish
SO  - Biomaterials. 2005 Jun;26(16):3215-25. doi: 10.1016/j.biomaterials.2004.09.012.